COMPARE HISTOLOGIC FEATURES/MR OF KIDNEYS IN LUPUS NEPHRITIS

比较狼疮性肾炎肾脏的组织学特征/MR

• 批准号: 8363184
• 负责人: Joshua M Thurman
• 金额: $ 0.61万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363184
• 关键词: Adverse effects; Autoimmune Process; Biopsy; Cicatrix; Contrast Media; Diagnosis; Disease; Electron Microscopy; Fibrosis; Funding; Goals; Grant; Hemorrhage; Histologic; Immunofluorescence Microscopy; Immunosuppressive Agents; Kidney; Kidney Diseases; Lupus Nephritis; Magnetic Resonance Imaging; Methods; Microscopy; Monitor; National Center for Research Resources; Patients; Principal Investigator; Process; Renal Tissue; Research; Research Infrastructure; Resources; Risk; Sampling; Source; United States National Institutes of Health; cost; imaging modality; improved; light microscopy; molecular imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of this project is to develop methods to non-invasively detect and monitor renal disease. Currently, the accurate diagnosis of autoimmune renal diseases such as lupus nephritis requires a percutaneous renal biopsy. The immunosuppressive agents used to treat these diseases are associated with many side-effects, and patients whose disease has caused significant fibrosis and scarring may not benefit from these therapies. Although generally safe, biopsies do carry a risk of bleeding and other complications. Furthermore, by sampling only a small piece of renal tissue the biopsy may not accurately reflect disease throughout both kidneys. Therefore, methods to non-invasively assess disease activity could greatly improve our ability to treat these patients. State-of-the-art imaging methods have not yet been applied to these questions. Our objective is to determine whether MRI can provide the same or better information than is currently obtained by renal biopsy. A renal biopsy is typically processed for light microscopy, immunofluorescence microscopy, and electron microscopy. We believe that MRI may provide information equivalent to that obtained by light microscopy. We are also currently developing targeted contrast agents for molecular imaging. These agents may provide the same information as is currently obtained by immunofluorescence microscopy.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的总体目标是开发非侵入性检测和监测肾脏疾病的方法。目前，狼疮性肾炎等自身免疫性肾脏疾病的准确诊断需要经皮肾活检。用于治疗这些疾病的免疫抑制剂与许多副作用相关，并且其疾病引起显著纤维化和瘢痕形成的患者可能无法从这些疗法中获益。虽然通常是安全的，但活检确实有出血和其他并发症的风险。此外，通过仅取样一小片肾组织，活检可能不能准确地反映整个肾脏的疾病。因此，非侵入性评估疾病活动的方法可以大大提高我们治疗这些患者的能力。 最先进的成像方法尚未应用于这些问题。我们的目的是确定MRI是否能提供与目前肾活检相同或更好的信息。肾活检通常进行光学显微镜、免疫荧光显微镜和电子显微镜检查。我们相信MRI可以提供与光学显微镜所获得的信息相当的信息。我们目前还在开发用于分子成像的靶向造影剂。这些试剂可以提供与目前通过免疫荧光显微镜获得的信息相同的信息。