SESTRIN IS A FEEDBACK INHIBITOR OF TOR THAT PREVENTS AGE-RELATED PATHOLOGIES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 与NCMIR的Guy Perkins合作的目的是研究Sestrin蛋白调节雷帕霉素靶标(TOR)的机制。NCMIR的电子显微镜和线粒体微解剖资源将用于阐明果蝇Sestrin基因敲除的骨骼和心肌的结构表型和治疗干预。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this collaboration with Guy Perkins of NCMIR is to investigate the mechanism by which the protein sestrin regulates target of rapamycin (TOR). The electron microscopy and mitochondrial microanatomy resources of the NCMIR will be used to elucidate structural phenotypes of sestrin knock-out skeletal and heart muscle in Drosophila fly and therapeutic intervention.