REGULATORY MECHANISM OF HEPARIN/HEPARAN SULFATE ON VEGF SIGNALING

肝素/硫酸乙酰肝素对 VEGF 信号传导的调节机制

• 批准号: 8361866
• 负责人: Lianchun Wang
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361866
• 关键词: Biological; Cell Line; Collaborations; Endothelial Cells; Funding; Grant; Heparin; Heparitin Sulfate; Mus; Mutant Strains Mice; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Signal Transduction; Source; United States National Institutes of Health; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; cost; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Heparin and heparin-like molecules are known to modulate the responses of endothelial cells to vascular endothelial growth factor-A (VEGF-A). In this collaboration, we have been investigating the likely mechanisms for heparin/heparan sulfate's influence on the biological activity of VEGF-A using heparan sulfate deficient mouse endothelial cell lines derived from heparan sulfate mutant mice.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 肝素及类肝素分子可调节血管内皮细胞对血管内皮生长因子-A(VEGF-A)的反应。在这项合作中，我们一直在研究肝素/硫酸肝素对血管内皮生长因子-A生物活性的影响的可能机制，使用硫酸肝素缺乏的小鼠内皮细胞系来自硫酸肝素突变小鼠。