ROLE OF CALCIUM-INDEPENDENT PHOSPHOLIPASE A2BETA IN HIGH GLUCOSE-INDUCED

钙非依赖性磷脂酶 A2β 在高血糖诱导中的作用

• 批准号: 8361445
• 负责人: Zhenheng Guo
• 金额: $ 0.83万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361445
• 关键词: Calcium; Diabetes Mellitus; Funding; Glucose; Grant; Link; Mass Spectrum Analysis; National Center for Research Resources; Phospholipase; Principal Investigator; Research; Research Infrastructure; Resources; Rho-associated kinase; Role; Signal Transduction; Source; United States National Institutes of Health; Vascular Smooth Muscle; biomedical resource; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Previous studies suggest that high glucose-induced RhoA/Rho kinase/CPI-17 activation is involved in diabetes-associated vascular smooth muscle hypercontractility. However, the upstream signaling that links high glucose and RhoA/Rho kinase/CPI-17 activation is unknown.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 先前的研究表明，高葡萄糖诱导的 RhoA/Rho 激酶/CPI-17 激活与糖尿病相关的血管平滑肌收缩过度有关。然而，连接高血糖和 RhoA/Rho 激酶/CPI-17 激活的上游信号传导尚不清楚。