DECREASED CLEARANCE OF CNS AMYLOID-? IN ALZHEIMER?S DISEASE

中枢神经系统淀粉样蛋白清除率降低？

• 批准号: 8361468
• 负责人: RANDALL J BATEMAN
• 金额: $ 1.31万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361468
• 关键词: Alzheimer' s Disease; Amyloid; Development; Disease; Funding; Grant; Mass Spectrum Analysis; National Center for Research Resources; Principal Investigator; Production; Research; Research Infrastructure; Resources; Source; Therapeutic Agents; United States National Institutes of Health; biomedical resource; cost

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Alzheimer's disease is hypothesized to be caused by A¿ disequilibrium leading to increased A¿ in the CNS. A¿ production and clearance have both been postulated to be the cause of A¿ disequilibrium and are key targets in the development of disease modifying therapeutic agents for Alzheimer's disease.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 阿尔茨海默氏病被认为是由于中枢神经系统中A？失衡导致A？升高所致。A？的产生和清除都被认为是A？不平衡的原因，也是开发阿尔茨海默病疾病改良剂的关键靶点。