THE FUNCTIONAL ORGANIZATION OF AXONS

轴突的功能组织

• 批准号: 8363802
• 负责人: MATTHEW N RASBAND
• 金额: $ 0.49万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363802
• 关键词: Action Potentials; Axon; Epilepsy; Funding; Generations; Grant; Ion Channel; Mass Spectrum Analysis; Multiple Sclerosis; Myasthenia Gravis; National Center for Research Resources; Nervous system structure; Neurons; Neurotransmitter Receptor; Play; Principal Investigator; Proteins; Ranvier' s Nodes; Research; Research Infrastructure; Resources; Role; Schizophrenia; Signal Transduction; Site; Source; Spinal cord injury; United States National Institutes of Health; Work; cost; density; painful neuropathy; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The generation, propagation, and modulation of electrical signals in the nervous system require the precise subcellular localization of ion channels in neurons. For example, disrupted ion channel or neurotransmitter receptor distribution or density play important roles in neuropathic pain, spinal cord injury, schizophrenia, myasthenia gravis, epilepsy, and multiple sclerosis. Two of the best examples of ion channel/receptor clustering in the nervous system are found along axons at and near the node of Ranvier (nodes, paranodes, and juxtaparanodes) and the axon initial segment. Ion channels clustered at these sites play key roles in regulating action potential generation and propagation. However, very little is known about the mechanisms regulating localization and retention of proteins at the AIS and nodes of Ranvier. A major impediment to understanding how ion channels are clustered at axon initial segments and nodes of Ranvier is the relatively few numbers of proteins that have been identified at these sites. In this project, we will work to identify new components of nodes, paranodes, juxtaparanodes, and axon initial segments.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 神经系统中电信号的产生、传播和调制需要神经元中离子通道的精确亚细胞定位。 例如，破坏的离子通道或神经递质受体分布或密度在神经性疼痛、脊髓损伤、精神分裂症、重症肌无力、癫痫和多发性硬化中起重要作用。 神经系统中离子通道/受体聚集的两个最好的例子是沿着朗维尔结（结、旁结和旁结）和轴突起始段处和附近的轴突。 聚集在这些位点的离子通道在调节动作电位的产生和传播中起关键作用。 然而，很少有人知道的机制，调节本地化和保留的蛋白质在AIS和节点的兰维尔。 理解离子通道如何聚集在轴突初始节段和Ranvier节点的一个主要障碍是在这些位点已鉴定的蛋白质数量相对较少。 在这个项目中，我们将致力于识别节点，paranodes，parentaparanodes和轴突初始段的新组件。