STUDIES OF WTR DYNAMICS BY T1RHO AND T2RHO MRI IN ACUTE CEREBRAL ISCHEMIA RAT

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 旋转帧弛豫MRI对比度，T1 rho和T2 rho，被认为是超急性卒中组织变化的敏感指标。在这项工作中，我们正在调查的变化，T1 rho和T2 rho MRI的梗死脑，最近表明，在超急性中风的变化反映了自由水池的大小增加，减少翻滚的水分子与大分子，并增加自由和大分子网站之间的水交换。这些发现与血管源性水肿、破坏性过程和组织酸化一致。这项研究为脑缺血的物理化学过程提供了新的见解

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Rotating frame relaxation MRI contrast, T1rho and T2rho, are thought to provide sensitive indicators of tissue changes in hyperacute stroke. In this work, we are investigating the changes in T1rho and T2rho MRI of infarcting brain, and have recently shown that the changes in hyperacute stroke reflect an increase in the free water pool size, decreased tumbling of the water molecules associated with macromolecules, and increased water exchange between free and macromolecular sites. These findings are consistent with vasogenic edema, destructive processes and tissue acidification. This research is providing new insights into the physico-chemical processes occurring in brain ischemia