IDENTIFICATION OF ENDOPHENOTYPES FOR BIPOLAR DISORDER

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 描述(由申请者提供)：此资助申请是通过以患者为导向的研究职业发展奖(K23)计划提供的5年资助。目的是发展候选人在行为遗传学研究方面的技能，并加强她在双相情感障碍神经生物学内表型方面的培训。该研究计划建立在候选人在重大精神疾病(精神分裂症和双相情感障碍)的行为表型和神经认知方面的经验基础上；其基本目标是评估严重双相情感障碍患者未受影响的亲属的神经认知功能、气质和神经解剖学指标的家族聚集性，并将这些指标应用于数量性状基因座(QTL)分析。这项拟议的研究将向将双极内表型与特定基因联系起来的最终目标迈出重要的第一步。研究和培训计划都是机会主义的，利用了之前从正在进行的研究中确定的研究样本，以及加州大学洛杉矶分校研究界的知名研究人员。职业发展计划将在以下方面发展PI的技能：1)收集和分析人类遗传物质的研究设计；2)用于检查遗传对认知和神经再生的影响的数据分析方法；以及3)数量性状基因座的分析。职业发展的方法包括：1)拟议的研究，2)纳尔逊·弗雷默博士和泰隆·坎农博士的指导，3)行为和统计遗传学专家的咨询，4)统计遗传学方法学和脑成像的正式课程工作，5)参加科学会议，6)为向同行评议的期刊提交手稿做数据准备。考虑到候选人之前的培训、拟议的导师、出色的资源和研究环境，K23奖项将使她成为双相情感障碍遗传学和神经生物学基础方面的成功和独立的研究员。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): This grant application is for 5 years of funding through the Mentored Patient Oriented Research Career Development Award (K23) program. The objective is to develop the candidate's skills in behavioral genetics research and augment her training in neurobiological endophenotypes of bipolar disorder. The research plan builds on the candidate's experience in behavioral endophenotypes and neurocognition in major mental illness (schizophrenia and bipolar disorder); its basic aim is to assess familial aggregation of measures of neurocognitive function, temperament, and neuroanatomy in unaffected relatives of individuals with severe bipolar disorder, and apply these measures to quantitative trait loci (QTL) analysis. The proposed study will provide an important first step toward the ultimate goal of linking bipolar endophenotypes to specific genes. Both the research and training plan are opportunistic, utilizing previously ascertained study samples from ongoing research, and renowned investigators in the UCLA research community. The Career Development Plan will develop the Pi's skills in: 1) the design of studies that collect and analyze human genetic material, 2) data analytic methods used to examine genetic effects on cognition and neuroanatony, and 3) analysis of quantitative trait loci. Methods of career development include: 1) the proposed study, 2) the mentorship of Drs. Nelson Freimer and Tyrone Cannon , 3) consultation with experts in behavioral and statistical genetics, 4) formal coursework in statistical genetics methodology and brain mapping, 5) attendance at scientific meetings, and 6) data preparation for submission of manuscripts to peer-reviewed journals. Given the candidate's prior training, proposed mentorship, outstanding resources and research environment, a K23 award will allow her to become a successful and independent investigator in the genetics and neurobiological bases of bipolar disorder.