WOUND HEALING AND EXTRACELLULAR MATRIX REMODELING IN THE LUNGS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 超过10%的美国人口患有哮喘，其发病率和患病率还在上升。该病的一个关键特征是气道壁的结构变化，随着疾病的进展，这种变化变得更加突出，并与疾病的严重程度和症状相关。目前尚不清楚这些变化是对异常损伤的正常反应，还是反应本身异常。此外，目前还没有足够的信息来描述气道重塑的机制，以确定结构变化是否可逆。气道壁的主要变化包括黏液细胞增生、上皮下纤维化、血管生成和平滑肌细胞增生。我们正在开发体外模型来解决所有这些特征，中心假设是支气管上皮细胞协调和调节这些过程中的每一个。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bronchial asthma afflicts more than 10% of the U.S. population, and the incidence and prevalence are on the rise. A critical feature of the disease is structural changes in the wall of the airways, which become more prominent as the disease progresses, and are correlated with disease severity and symptoms. It is not clear whether these changes are a normal response to an abnormal injury, or whether the response itself is abnormal. In addition, there is inadequate information describing the mechanisms of airway remodeling to determine whether the structural changes are reversible. The major changes in the airway wall include mucus cell hyperplasia, subepithelial fibrosis, angiogenesis, and smooth muscle cell hyperplasia. We are developing in vitro models to address all of these features, with a central hypothesis that the bronchial epithelial cell orchestrates and modulates each of these processes.