WOUND HEALING AND EXTRACELLULAR MATRIX REMODELING IN THE LUNGS

肺部伤口愈合和细胞外基质重塑

• 批准号: 8365761
• 负责人: Steven CARL George
• 金额: $ 0.2万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-20 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365761
• 关键词: Address; Asthma; Cells; Disease; Epithelial Cells; Extracellular Matrix; Fibrosis; Fluorescence; Funding; Grant; Hyperplasia; Incidence; Injury; Laboratories; Lung; Mucous body substance; National Center for Research Resources; Population; Prevalence; Principal Investigator; Process; Research; Research Infrastructure; Resources; Severity of illness; Smooth Muscle Myocytes; Source; Symptoms; United States National Institutes of Health; Wound Healing; airway remodeling; angiogenesis; cost; in vitro Model; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bronchial asthma afflicts more than 10% of the U.S. population, and the incidence and prevalence are on the rise. A critical feature of the disease is structural changes in the wall of the airways, which become more prominent as the disease progresses, and are correlated with disease severity and symptoms. It is not clear whether these changes are a normal response to an abnormal injury, or whether the response itself is abnormal. In addition, there is inadequate information describing the mechanisms of airway remodeling to determine whether the structural changes are reversible. The major changes in the airway wall include mucus cell hyperplasia, subepithelial fibrosis, angiogenesis, and smooth muscle cell hyperplasia. We are developing in vitro models to address all of these features, with a central hypothesis that the bronchial epithelial cell orchestrates and modulates each of these processes.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 支气管哮喘困扰着超过10%的美国人口，并且发病率和患病率都在上升。该疾病的一个关键特征是气道壁的结构变化，其随着疾病进展而变得更加突出，并且与疾病严重程度和症状相关。目前尚不清楚这些变化是否是对异常损伤的正常反应，或者反应本身是否异常。此外，没有足够的信息描述气道重塑的机制，以确定结构变化是否可逆。气道壁的主要变化包括粘液细胞增生、上皮下纤维化、血管生成和平滑肌细胞增生。我们正在开发体外模型来解决所有这些特征，其中心假设是支气管上皮细胞协调和调节这些过程。