7th International Conference on Fe-S Cluster Biogenesis and Regulation

第七届Fe-S簇生物发生与调控国际会议将于2013年5月20 - 24日在美国南卡罗来纳州哥伦比亚市举行。这次会议是两年一次的Fe-S集群生物发生和代谢系列会议的最新一次会议，该会议已成为这个迅速发展的领域中不同研究人员的主要会议。铁硫（Fe-S）簇被蛋白质用作辅助因子，用于细胞内的无数功能，从金属酶中的电子转移和底物激活到金属调节蛋白中的活性氧和氮传感器。Fe-S簇在细胞中组装，以响应代谢需求和环境条件的变化，使用复杂的蛋白质网络进行铁和硫的动员，重新组装簇，以及靶向金属蛋白的簇运输。一种特殊的力量

DESCRIPTION (provided by applicant): The 7th International Conference on Fe-S Cluster Biogenesis and Regulation will take place in Columbia, South Carolina from May 20 - 24, 2013. This conference is the latest in a biennial series of conferences on Fe-S cluster biogenesis and metabolism that has become the principal meeting for a diverse group of researchers in this rapidly expanding field. Iron-sulfur (Fe-S) clusters are used as cofactors by proteins for myriad functions within the cell, ranging from electron transfer and substrate activation in metalloenzymes to reactive oxygen and nitrogen sensors in metalloregulatory proteins. Fe-S clusters are assembled in cells in response to changes in metabolic demand and environmental conditions using a complex network of proteins that carry out iron and sulfur mobilization, de novo cluster assembly, and trafficking of clusters to target metalloproteins. A particular strength of this conference has been its ability to bring together scientists focused on understanding the molecular details of Fe-S protein maturation and scientists/medical doctors studying the direct impact of Fe-S cluster metabolism on human health. Over the last decade it has become clear that disruption of Fe-S cluster formation and delivery can lead to a variety of human diseases such as Friedreich¿s ataxia, X-linked sideroblastic anemia, sideroblastic-like microcytic anemia, and various myopathies and mitochondrial dysfunction disorders. This meeting promotes integrated discussion of the fundamental biochemistry and molecular biology of Fe-S cluster biogenesis to help define the pathology of human diseases associated with dysregulation of iron metabolism. Currently there is no other meeting series that accomplishes this important task.