7th International Conference on Fe-S Cluster Biogenesis and Regulation

第七届铁硫簇生物发生与调控国际会议

• 批准号: 8529798
• 负责人: Franklin Wayne Outten
• 金额: $ 0.4万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8529798
• 关键词: Animal Model; Applied Research; Basic Science; Biochemistry; Biogenesis; Biology; Cells; Chemistry; Clinical; Clinical Sciences; Collaborations; Communities; Complex; Defect; Development; Disabled Persons; Discipline; Disease; Electron Transport; Enzymatic Biochemistry; Enzymes; Exposure to; Fertilization; Fostering; Friedreich Ataxia; Funding; Health; Hereditary Disease; Human; Human Genetics; International; Iron; Lead; Life; Link; Medical; Mentors; Metabolic; Metabolism; Metalloproteins; Metals; Molecular; Molecular Biology; Molecular Chaperones; Myopathy; Nitrogen; Nitrogenase; Oral; Organism; Oxygen; Participant; Pathology; Phylogenetic Analysis; Physicians; Play; Process; Protein S; Proteins; Recruitment Activity; Regulation; Request for Proposals; Research; Research Personnel; Role; Scientific Advances and Accomplishments; Scientist; Series; Sideroblastic Anemia; South Carolina; Spectrum Analysis; Sulfides; Sulfur; Sum; System; Underrepresented Minority; Universities; Woman; Work; abstracting; career; cofactor; human disease; insight; iron metabolism; meetings; metalloenzyme; metalloregulatory protein; microcytic anemia; mitochondrial dysfunction; posters; public health relevance; response; scaffold; sensor; success; symposium; trafficking

DESCRIPTION (provided by applicant): The 7th International Conference on Fe-S Cluster Biogenesis and Regulation will take place in Columbia, South Carolina from May 20 - 24, 2013. This conference is the latest in a biennial series of conferences on Fe-S cluster biogenesis and metabolism that has become the principal meeting for a diverse group of researchers in this rapidly expanding field. Iron-sulfur (Fe-S) clusters are used as cofactors by proteins for myriad functions within the cell, ranging from electron transfer and substrate activation in metalloenzymes to reactive oxygen and nitrogen sensors in metalloregulatory proteins. Fe-S clusters are assembled in cells in response to changes in metabolic demand and environmental conditions using a complex network of proteins that carry out iron and sulfur mobilization, de novo cluster assembly, and trafficking of clusters to target metalloproteins. A particular strength of this conference has been its ability to bring together scientists focused on understanding the molecular details of Fe-S protein maturation and scientists/medical doctors studying the direct impact of Fe-S cluster metabolism on human health. Over the last decade it has become clear that disruption of Fe-S cluster formation and delivery can lead to a variety of human diseases such as Friedreich¿s ataxia, X-linked sideroblastic anemia, sideroblastic-like microcytic anemia, and various myopathies and mitochondrial dysfunction disorders. This meeting promotes integrated discussion of the fundamental biochemistry and molecular biology of Fe-S cluster biogenesis to help define the pathology of human diseases associated with dysregulation of iron metabolism. Currently there is no other meeting series that accomplishes this important task.

描述（由申请人提供）：第七届铁硫簇生物发生和调节国际会议将于2013年5月20日至24日在南卡罗来纳州的哥伦比亚举行。本次会议是关于Fe-S簇生物发生和代谢的两年一次的系列会议中的最新一次，该会议已成为这一迅速扩大的领域中各种研究人员的主要会议。铁-硫（Fe-S）簇被蛋白质用作细胞内无数功能的辅因子，从金属酶中的电子传递和底物活化到金属调节蛋白中的活性氧和氮传感器。Fe-S簇在细胞中组装，以响应代谢需求和环境条件的变化，使用复杂的蛋白质网络进行铁和硫的动员，从头簇组装，并将簇运输到靶金属蛋白。特定强度 本次会议的一个亮点是它能够将专注于了解Fe-S蛋白质成熟的分子细节的科学家和研究Fe-S簇代谢对人类健康的直接影响的科学家/医生聚集在一起。在过去的十年中，已经清楚的是，Fe-S簇形成和递送的破坏可以导致多种人类疾病，如弗里德赖希共济失调，X连锁铁粒幼细胞性贫血，铁粒幼细胞样小细胞性贫血，以及各种肌病和线粒体功能障碍。本次会议促进了Fe-S簇生物发生的基础生物化学和分子生物学的综合讨论，以帮助定义与铁代谢失调相关的人类疾病的病理学。目前没有其他会议系列来完成这一重要任务。