CANCER TISSUE AND PATHOLOGY SHARED RESOURCE

癌症组织和病理学共享资源（类别4.06）对于Winship癌症研究所的临床和科学成功至关重要，因为它在促进基于组织的研究方面发挥着核心作用，通过采购人类癌症标本和全面的组织病理学服务。该资源是高度集成的，在所有主要项目中为个人和团队项目提供服务，并直接与其他共享资源交互。组织库组成部分包括IRB批准的人体组织采购服务（HTPS），位于Emory University Hospital和Winship内，附属库地点位于Grady Memorial、Emory Midtown和Children's Healthcare of Atlanta at Egleston。采购人员在解剖病理学和肿瘤库方案方面经验丰富，病理学部门成员提供质量保证。肿瘤、正常对照组织和血液，沿着其他生物样本按照专门方案，按照标准化操作程序作为冷冻、新鲜、固定、包埋或其他专门制备物进行采购，并在caTissue Core（一种用于生物样本库的caBIG工具）中进行库存。超过55，000个样本可用。组织被分发给Winship研究人员，并附有IRB批准的方案，以推进临床、转化、基础和流行病学研究。病理学服务由研究病理学实验室提供，这是一个位于Winship大楼5楼的全方位服务实验室，拥有经验丰富的人员和设备，用于组织处理，组织学和免疫组织化学染色，激光捕获显微镜，组织微阵列和数字病理学的全载玻片扫描。实验室流程 我们的研究团队拥有大量来自人类疾病和动物模型的样本，并与Winship的其他共享资源和科学计划密切合作，这体现在研究生产力和团体科学赠款的支持上。这种共享资源的日益成功突出体现在其在多个NCI驱动的计划中的领导地位，包括caBIG，TCGA和caHUB。该共享资源提供集中，高效和高质量的服务，不会被校园内的其他设施重复。

The Cancer Tissue and Pathology Shared Resource (Category 4.06) is critical to the clinical and scientific success of the Winship Cancer Institute because of its central role in facilitating tissue-based investigation though the procurement of human cancer specimens and comprehensive histopathologic services. The Resource is highly integrated, serving individual and team projects in all of the major programs and interfacing directly with the other Shared Resources. The tissue banking component consists of an IRB approved Human Tissue Procurement Service (HTPS), located within the Emory University Hospital and Winship, with affiliated banking sites at Grady Memorial, Emory Midtown and Children's Healthcare of Atlanta at Egleston. Procurement personnel are experienced in anatomic pathology and tumor banking protocols with quality assurance provided by members of the Department of Pathology. Tumor, normal control tissues and blood, along with other biospecimens on specialized protocols, are procured according to standardized operating procedures as frozen, fresh, fixed, embedded or other specialized preparation, and inventoried in caTissue Core, a caBIG tool for biospecimen repositories. Over 55,000 specimens are available. Tissues are distributed to Winship investigators with IRB-approved protocols to advance clinical, translational, basic and epidemiologic research. Pathology services are provided by the Research Pathology Laboratory, a full service lab located on the 5th floor of the Winship building with experienced personnel and equipment for tissue processing, histological and immunohistochemical staining, laser capture microscopy, tissue microarrays and a whole slide scanning for digital pathology. The lab processes large volumes of samples derived from human disease and animal models and works in close collaboration with the other Shared Resources and scientific programs of Winship, as demonstrated by research productivity and support of group science grants. The growing success of this Shared Resource is highlighted by its leadership in multiple NCI-driven initiatives, including caBIG, TCGA and caHUB. This Shared Resource provides centralized, efficient and high quality services that are not duplicated by other facilities on campus.