CANCER TISSUE AND PATHOLOGY SHARED RESOURCE

癌症组织和病理共享资源(4.06类)对Winship癌症研究所的临床和科学成功至关重要，因为它通过采购人类癌症标本和全面的组织病理学服务，在促进基于组织的研究方面发挥了核心作用。该资源是高度集成的，为所有主要计划中的个人和团队项目提供服务，并直接与其他共享资源交互。组织银行部分由IRB批准的人体组织采购服务(HTPS)组成，位于埃默里大学医院和Winship，在格雷迪纪念馆、埃默里中城和亚特兰大儿童保健埃格尔斯顿设有附属银行网站。采购人员在解剖病理学和肿瘤库方案方面经验丰富，并由病理学系成员提供质量保证。肿瘤、正常对照组织和血液，以及按照专门规程的其他生物检验剂，根据标准化的操作程序，如冷冻、新鲜、固定、包埋或其他专门制剂，被采购，并存入caTIssue Core，这是一个用于生物检验库的caBIG工具。目前有超过55,000个标本可供选择。组织按照IRB批准的方案分发给Winship研究人员，以推进临床、翻译、基础和流行病学研究。病理学服务由研究病理实验室提供，这是一个位于Winship大楼5楼的全方位服务实验室，拥有经验丰富的人员和设备，用于组织处理、组织学和免疫组织化学染色、激光捕获显微镜、组织微阵列和用于数字病理的整个载玻片扫描。实验室流程 大量样本来自人类疾病和动物模型，并与Winship的其他共享资源和科学计划密切合作，研究效率和小组科学拨款的支持证明了这一点。这一共享资源日益成功的突出表现是，它在包括caBIG、TCGA和caHUB在内的多个NCI驱动的倡议中发挥了领导作用。这种共享资源提供了集中化、高效和高质量的服务，这是校园内其他设施无法复制的。

The Cancer Tissue and Pathology Shared Resource (Category 4.06) is critical to the clinical and scientific success of the Winship Cancer Institute because of its central role in facilitating tissue-based investigation though the procurement of human cancer specimens and comprehensive histopathologic services. The Resource is highly integrated, serving individual and team projects in all of the major programs and interfacing directly with the other Shared Resources. The tissue banking component consists of an IRB approved Human Tissue Procurement Service (HTPS), located within the Emory University Hospital and Winship, with affiliated banking sites at Grady Memorial, Emory Midtown and Children's Healthcare of Atlanta at Egleston. Procurement personnel are experienced in anatomic pathology and tumor banking protocols with quality assurance provided by members of the Department of Pathology. Tumor, normal control tissues and blood, along with other biospecimens on specialized protocols, are procured according to standardized operating procedures as frozen, fresh, fixed, embedded or other specialized preparation, and inventoried in caTissue Core, a caBIG tool for biospecimen repositories. Over 55,000 specimens are available. Tissues are distributed to Winship investigators with IRB-approved protocols to advance clinical, translational, basic and epidemiologic research. Pathology services are provided by the Research Pathology Laboratory, a full service lab located on the 5th floor of the Winship building with experienced personnel and equipment for tissue processing, histological and immunohistochemical staining, laser capture microscopy, tissue microarrays and a whole slide scanning for digital pathology. The lab processes large volumes of samples derived from human disease and animal models and works in close collaboration with the other Shared Resources and scientific programs of Winship, as demonstrated by research productivity and support of group science grants. The growing success of this Shared Resource is highlighted by its leadership in multiple NCI-driven initiatives, including caBIG, TCGA and caHUB. This Shared Resource provides centralized, efficient and high quality services that are not duplicated by other facilities on campus.