CANCER TISSUE AND PATHOLOGY SHARED RESOURCE

癌症组织和病理学共享资源

• 批准号: 8512147
• 负责人: DANIEL J BRAT
• 金额: $ 11.34万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8512147
• 关键词: Anatomy; Animal Model; Basic Science; Blood; Cancer Center Support Grant; Categories; Child; Clinical; Clinical Research; Collaborations; Consent; Epidemiologic Studies; Equipment; Equipment and supply inventories; Floor; Freezing; Grant; Healthcare; Human; Human Resources; Individual; Institutes; Institutional Review Boards; Investigation; Laboratories; Lasers; Leadership; Malignant Neoplasms; Microscopy; Mission; Pathology; Patients; Preparation; Procedures; Process; Productivity; Protocols documentation; Research; Research Personnel; Resource Sharing; Resources; Role; Sampling; Scanning; Science; Services; Site; Slide; Source; Specimen; Staining method; Stains; Support Groups; The Cancer Genome Atlas; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Bank; University Hospitals; Work; base; cancer Biomedical Informatics Grid; digital; experience; human disease; human tissue; member; programs; quality assurance; repository; success; tissue processing; tool; tumor

The Cancer Tissue and Pathology Shared Resource (Category 4.06) is critical to the clinical and scientific success of the Winship Cancer Institute because of its central role in facilitating tissue-based investigation though the procurement of human cancer specimens and comprehensive histopathologic services. The Resource is highly integrated, serving individual and team projects in all of the major programs and interfacing directly with the other Shared Resources. The tissue banking component consists of an IRB approved Human Tissue Procurement Service (HTPS), located within the Emory University Hospital and Winship, with affiliated banking sites at Grady Memorial, Emory Midtown and Children's Healthcare of Atlanta at Egleston. Procurement personnel are experienced in anatomic pathology and tumor banking protocols with quality assurance provided by members of the Department of Pathology. Tumor, normal control tissues and blood, along with other biospecimens on specialized protocols, are procured according to standardized operating procedures as frozen, fresh, fixed, embedded or other specialized preparation, and inventoried in caTissue Core, a caBIG tool for biospecimen repositories. Over 55,000 specimens are available. Tissues are distributed to Winship investigators with IRB-approved protocols to advance clinical, translational, basic and epidemiologic research. Pathology services are provided by the Research Pathology Laboratory, a full service lab located on the 5th floor of the Winship building with experienced personnel and equipment for tissue processing, histological and immunohistochemical staining, laser capture microscopy, tissue microarrays and a whole slide scanning for digital pathology. The lab processes large volumes of samples derived from human disease and animal models and works in close collaboration with the other Shared Resources and scientific programs of Winship, as demonstrated by research productivity and support of group science grants. The growing success of this Shared Resource is highlighted by its leadership in multiple NCI-driven initiatives, including caBIG, TCGA and caHUB. This Shared Resource provides centralized, efficient and high quality services that are not duplicated by other facilities on campus.

癌症组织和病理学共享资源（类别 4.06）对于 Winship 癌症研究所的临床和科学成功至关重要，因为它在通过采购人类癌症标本和综合组织病理学服务促进基于组织的研究方面发挥着核心作用。该资源高度集成，为所有主要计划中的个人和团队项目提供服务，并直接与其他共享资源连接。组织库部分由 IRB 批准的人体组织采购服务 (HTPS) 组成，该服务位于埃默里大学医院和 Winship 内，并在格雷迪纪念馆、埃默里市中心和埃格尔斯顿的亚特兰大儿童医疗保健中心设有附属库点。采购人员在解剖病理学和肿瘤库方案方面经验丰富，并由病理科成员提供质量保证。肿瘤、正常对照组织和血液，以及按照专门方案的其他生物样本，根据标准化操作程序作为冷冻、新鲜、固定、包埋或其他专门制备物进行采购，并存入caTissue Core（一种用于生物样本存储库的caBIG工具）中。提供超过 55,000 个样本。组织将按照 IRB 批准的方案分发给 Winship 研究人员，以推进临床、转化、基础和流行病学研究。病理学服务由研究病理学实验室提供，这是一个位于 Winship 大楼 5 楼的全方位服务实验室，拥有经验丰富的人员和设备，可进行组织处理、组织学和免疫组织化学染色、激光捕获显微镜、组织微阵列和数字病理学全玻片扫描。实验室流程 大量来自人类疾病和动物模型的样本，并与 Winship 的其他共享资源和科学项目密切合作，研究生产力和团体科学资助的支持就证明了这一点。该共享资源不断取得成功，其在多个 NCI 驱动的计划（包括 caBIG、TCGA 和 caHUB）中的领导地位凸显了这一点。这种共享资源提供集中、高效和高质量的服务，这是校园其他设施无法复制的。