Tolerance of Kidney and Islet Transplants via the Mixed Chimerism Approach

通过混合嵌合方法进行肾脏和胰岛移植的耐受性

• 批准号: 8432084
• 负责人: TATSUO KAWAI
• 金额: $ 64.36万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8432084
• 关键词: Allogenic; Allograft Tolerance; Allografting; Cells; Chimerism; Chronic; Goals; Human; Immune Tolerance; Immunosuppression; Instruction; Kidney; Kidney Transplantation; Laboratories; Modality; Modeling; Organ; Organ Transplantation; Population; Prevention; Regimen; Research; Research Proposals; Translating; Transplant Recipients; Transplantation; base; clinical application; conditioning; islet; islet allograft; kidney allograft; nonhuman primate; novel; novel strategies

PROJECT SUMMARY (See instructions): Induction of specific immunologic tolerance is an ultimate goal of organ transplantation. Based on the conditioning regimen developed in our laboratory by decades-long research in nonhuman primates (NHP), we have now successfully achieved renal allograft tolerance in HLA mismatched human kidney transplant recipients via the mixed chimerism approach. However, limitations of this approach have been its inapplicability for deceased donor transplantation and the inability to induce tolerance of non-renal organs/cells. To extend this approach to deceased donor transplantation, we recently developed a novel strategy of

项目总结（见说明）： 诱导特异性免疫耐受是器官移植的最终目标。基于我们实验室在非人灵长类动物（NHP）中长达数十年的研究开发的预处理方案，我们现在已经成功地通过混合嵌合体方法在HLA不匹配的人肾移植受者中实现了肾移植耐受。然而，这种方法的局限性在于其 不适用于死亡供体移植和不能诱导非肾器官/细胞的耐受。为了将这种方法扩展到死亡供体移植，我们最近开发了一种新的策略，