B Cell Epitope Discovery: Dengue, Hepatitis C, Ebola, and Chikungunya viruses

B细胞表位发现和抗体产生机制计划的目标是识别新的B细胞表位，并阐明抗体介导的保护或致病的新机制，这些机制在人类对新出现和再次出现的传染病和潜在的生物恐怖主义及其毒素的体液免疫中具有重要作用。这一B细胞表位发现计划的结果将促进我们对抗体功能的了解，并极大地促进改进的免疫疗法、诊断和疫苗的设计和开发。此外，已知B细胞表位和抗体功能的扩大将有助于开发更强大的算法和数学模型来预测B细胞表位和抗体介导的体内对病原体和毒素的免疫反应。 这份合同将确定登革热病毒、丙型肝炎病毒、埃博拉病毒和基孔肯雅病毒的b细胞表位。

The goal of the B Cell Epitope Discovery and Mechanisms of Antibody Production program is to identify novel B cell epitopes and elucidate novel mechanisms of antibody-mediated protection or pathogenesis that are important in humoral immunity in humans to emerging and re-emerging infectious diseases and potential agents of bioterrorism and their toxins. Results from this B cell epitope discovery program will advance our understanding of antibody functions and greatly facilitate the design and development of improved immunotherapeutics, diagnostics, and vaccines. In addition, an expansion of the list of known B cell epitopes and antibody functions will facilitate the development of more robust algorithms and mathematical models to predict B cell epitopes and antibody-mediated immune responses to pathogens and toxins in vivo. This contract will identify b cell epitopes for Dengue virus, Hepatitis C virus, Ebola virus, and Chikungunya virus.