Physiologic Distress and Neuropsychiatric Behaviors in Alzheimer's Disease

阿尔茨海默病的生理困扰和神经精神行为

• 批准号: 8311569
• 负责人: Nancy A Hodgson
• 金额: $ 11.92万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-24 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8311569
• 关键词: Address; Advocate; Agitation; Alzheimer' s Disease; American; Basic Science; Behavior; Behavior Therapy; Behavioral; Benign; Biological; Biomedical Research; Caregivers; Caring; Clinical; Cognitive; Communities; Controlled Study; Data; Dementia; Development; Discipline; Disease; Disease Progression; Distress; Elderly; Family Caregiver; Frail Elderly; Frail Older Adults; Gerontology; Glean; Home environment; Individual; International; Intervention; Knowledge; Mediator of activation protein; Mentored Patient-Oriented Research Career Development Award; Motor; NIH Program Announcements; Neuroendocrinology; Neurosecretory Systems; Nurses; Outcome; Palliative Care; Parents; Patients; Physiological; Pilot Projects; Population; Process; Professional Organizations; Protocols documentation; Randomized; Randomized Controlled Trials; Recruitment Activity; Relative (related person); Research; Research Personnel; Research Training; Risk; Sampling; Sensory; Specificity; Stress; Symptoms; Tactile; Techniques; Technology; Testing; Training; Training Programs; Translating; Waiting Lists; abstracting; advanced dementia; base; behavioral/social science; career; design; expectation; improved; insight; neuropsychiatry; next generation; novel; patient oriented research; programs; response; satisfaction; treatment as usual

Abstract The aim of this NINR Mentored Patient Oriented Research Career Development Award application is to support my career objective to become an independent nurse investigator specializing in the relationship between neuroendocrine mechanisms and neuropsychiatric features of Alzheimer's disease (AD). Extensive basic research shows that neuroendocrine factors modulate core behavioral and cognitive processes. Recent findings indicate that neuroendocrine dysregulation influences the presentation of neuropsychiatric symptoms related to advancing AD. I propose a training plan that includes obtaining expertise in adrenocortical assessment, statistical design and analysis of studies integrating biological and behavioral data, and the design and testing of sensory-based interventions to alleviate neuroendocrine distress in older adults with AD. The proposed 3 year research plan represents a unique contribution to the field by merging the scientific insights and technologies gleaned from behavioral and social sciences with approaches from biomedical disciplines. The specific aims of the proposed research are: (1) to determine the preliminary efficacy of the sensory based, tactile protocol in alleviating distress in a sample of older adults with AD using neuroendocrine and behavioral responses as endpoints; and (2) to determine the acceptability of the sensory-based protocol based on satisfaction expressed by caregivers. A total of 78 AD patient-family caregiver dyads will be recruited to participate in a randomized wait-list control study. If this study finds evidence of preliminary efficacy and acceptability, an R01 application will be developed to conduct a larger randomized controlled trial. The expectation is that the findings from this program of study will ultimately result in treatments to slow the course and/or manage symptoms of those with advancing AD.

摘要 这个NINR指导的面向患者的研究职业发展奖的目的 申请是为了支持我成为一名独立护士的职业目标 专门研究神经内分泌机制与 阿尔茨海默病（AD）的神经精神病学特征。广泛的基础研究表明， 神经内分泌因子调节核心行为和认知过程。最近 研究结果表明，神经内分泌失调会影响 与进展性AD相关的神经精神症状。我提出一个训练计划， 包括获得肾上腺皮质评估，统计设计和 分析整合生物和行为数据的研究，以及设计和测试 以感觉为基础的干预措施，以减轻老年人的神经内分泌困扰， AD.拟议的3年研究计划代表了对该领域的独特贡献， 将从行为和社会学中收集到的科学见解和技术 科学与生物医学学科的方法。建议的具体目标 研究内容有：（1）初步确定疗效以感官为主，触觉为主 使用神经内分泌技术减轻老年AD患者痛苦的方案 和行为反应作为终点;（2）确定 基于照顾者表达的满意度的基于感觉的协议。共78次 将招募患者-家庭照顾者配对参与随机等待名单 对照研究如果本研究发现初步有效性和可接受性的证据， 将开发R 01应用程序以进行更大规模的随机对照试验。的 期望的是，这项研究计划的结果将最终导致 治疗，以减缓进程和/或管理那些与先进的AD症状。