Administrative Core

CEBASM的生物行为模型扩展了P20中心在相互作用方面的工作 关注生物行为临床科学进展的生物和行为现象 通过与复杂星座的生物行为机制、管理和结果相关的研究 一系列症状，包括常见的疲劳症状。生物行为研究的重点是 生物、行为和社会因素之间的相互作用及其对结果的影响 图2中所描述的内容已被各个项目主管用作 检查疲劳和相关的生物行为现象，这些现象与他们所参与的项目有关。具体目标 中心的项目包括对生物行为科学的研究，特别是对理解和管理 疲劳和相关症状星座及其对生物行为健康结局的影响 不同的人群。 作为CEBASM的指导性概念框架，扩展模型代表了 在危重健康的背景下生物和行为变量以及关键辅助因素的相互作用 经验。关键的健康体验包括健康方面的戏剧性变化或对 将个人置于危险之中的与健康的关系。症状体验以心理社会和 行为调节器(包括生物行为症状管理干预)与生物 调解人。在生物领域中心的研究集中在多维的相互作用上 可能引起症状的神经内分泌和免疫介质。这些复合体 危重健康经历背景下的相互作用被认为至少部分地解释了通常 出现的症状，如疲劳和心理困扰，最终，生物行为结果 心理社会功能、生活质量和身体健康领域。此外，还有众多主持人， 包括人的因素、已知和未知的混杂变量以及间接协变量 症状体验和生物行为健康结果。

The biobehavioral model for the CEBASM expands the work of the P20 Center on interactions among biological and behavioral phenomena by focusing on the advancement of biobehavioral clinical science through research related to biobehavioral mechanisms, management, and outcomes of complex constellations of symptoms, including the commonly occurring symptom of fatigue. Biobehavioral research focuses on the interactions among biological, behavioral, and social factors and their effects on outcomes\ The general model depicted in Figure 2 has been used by the individual Project Directors as a foundational framework for examining fatigue and associated biobehavioral phenomena specific to their pi^oposed projects. Specific aims of Center Projects include investigation of biobehavioral science specific to understanding and managing fatigue and associated symptom constellations and their impacts on biobehavioral health outcomes across diverse populations. Serving as the guiding conceptual framework for the CEBASM, the expanded model represents the interaction of biological and behavioral variables as well as critical cofactors in the context of a crifical health experience. A critical health experience involves a dramatic change in health or a perception of change in relation to health that places an individual at risk. The symptom experience unfolds as psychosocial and behavioral moderators (including biobehavioral symptom management interventions) interact with biological mediators. In the biological domain Center research focuses on the multidimensional interactions among neuroendocrine and immunological mediators that may underiie symptom constellafions. These complex interactions in the context of a crifical health experience are thought to explain, at least in part, commonly occurring symptoms such as fatigue and psychological distress and, ultimately, biobehavioral outcomes in the domains of psychosocial functioning, quality of life, and physical health. Additionally, numerous moderators, including person factors, known and unknown confounding variables, as well as indirect covariates, contribute to symptom experiences and biobehavioral health outcomes.