PROTEIN SCIENCE TRANSLATION CORE

蛋白质科学翻译核心

• 批准号: 8461050
• 负责人: YI-TE HSU
• 金额: $ 14.75万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8461050
• 关键词: Achievement; Antibodies; Awareness; Biological Assay; Cardiovascular Diseases; Cell Line; Centers of Research Excellence; Chemicals; Circular Dichroism; Clinical Sciences; Consultations; Diabetes Mellitus; Disease; Education; Enzymes; Escherichia coli; Extramural Activities; Faculty; Fatty acid glycerol esters; Fees; Funding; Grant; High Pressure Liquid Chromatography; Immunoprecipitation; In Vitro; Individual; Industry; Institutes; Label; Lipid Binding; Lipids; Malignant Neoplasms; Mammalian Cell; Mentors; Metabolic; Modification; NMR Spectroscopy; Nerve Degeneration; Phase; Postdoctoral Fellow; Preclinical Drug Evaluation; Production; Proteins; Proteomics; Recombinant Proteins; Recombinants; Regulation; Research; Research Institute; Research Personnel; Resources; Role; Science; Screening procedure; Services; Signal Transduction; South Carolina; Structure; Students; Suggestion; Surface Plasmon Resonance; System; Therapeutic; Translational Research; Translations; Validation; Western Blotting; Work; X-Ray Crystallography; base; design; drug development; drug discovery; fast protein liquid chromatography; high throughput screening; improved; inhibitor/antagonist; innovation; instrumentation; interest; light scattering; lipid metabolism; medical specialties; member; novel; physical state; pre-clinical; programs; protein expression; protein protein interaction; protein purification; protein structure function; structural biology; success

The Protein Science Translation Core was created to assist Investigators of the COBRE in Lipidomics and Pathobiology in studying structures and functions of proteins involved in the regulation of lipid metabolism and signaling. Over the years, the Core has transitioned from a strictly consultative role to a more active role in servicing investigators in various aspects of protein science. Moreover, as the bulk of research in the COBRE continues to evolve towards pre-clinical and translational sciences, the Core has become essential in supporting this effort by enabling studies on target validation and enzyme-targeted translational research and therapeutics. Since 2002, the Core has serviced more than 25 investigators and worked on 35 proteins. The aims of the Core during Phase III of COBRE funding are to: 1) produce proteins of interest for individual investigators that are needed for structural and functional characterization and for translational research programs at MUSC; 2) offer a wide range of protein-related specialty services to suit the needs of investigators and to coordinate the needs of Center investigators with other existing facilities at MUSC; and 3) enhance the understanding and capability of investigators in protein science through mentoring, consultation, and promotional seminars. Taken together, these aims will contribute to the scientific achievement of investigators in South Carolina whose research involve some aspects of protein science, which in the long run could contribute to the development of drugs against specific diseases. The usefulness and popularity of the Core will in turn enhance its prospect in achieving self-sustainability.

蛋白质科学翻译核心的创建是为了协助COBRE在脂质组学和病理生物学中的研究人员研究参与脂质代谢和信号传导调节的蛋白质的结构和功能。多年来，核心已经从严格的咨询角色转变为更积极的角色，在蛋白质科学的各个方面为研究人员提供服务。此外，随着COBRE的大部分研究继续向临床前和转化科学发展，Core通过支持靶标验证和酶靶向转化研究和治疗学的研究，在支持这一努力方面变得至关重要。自2002年以来，Core已经为超过25名研究人员提供了服务，研究了35种蛋白质。在COBRE资助的第三阶段，核心的目标是：1)为个体研究人员生产结构和功能表征所需的蛋白质，以及MUSC的转化研究项目；2)提供广泛的蛋白质相关专业服务，以满足研究人员的需求，并协调中心研究人员与MUSC其他现有设施的需求；3)通过指导、咨询和推广研讨会等方式，提高科研人员对蛋白质科学的理解和能力。总的来说，这些目标将有助于南卡罗来纳州研究人员的科学成就，他们的研究涉及蛋白质科学的某些方面，从长远来看，这些研究可能有助于开发针对特定疾病的药物。核心的有用性和受欢迎程度反过来将增强其实现自我可持续性的前景。