Mucosal biology scientific research support component

粘膜生物学科研支撑部分

• 批准号: 8385848
• 负责人: ROBIN J SHATTOCK
• 金额: $ 17.63万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8385848
• 关键词: AIDS/HIV problem; Adjuvant; Antibodies; Antibody Formation; Antigens; Biology; Cells; Characteristics; Clinical; Development; Epithelial; Event; Goals; HIV Infections; HIV Vaccine Trials Network; HIV-1; Human; Immunology; Infection; Modeling; Movement; Mucosal Immunity; Mucous body substance; Nature; Physiological; Rectum; Research Design; Research Support; Route; Series; Surface; Tissues; Vaccines; Vagina; Viral; Virion; nonhuman primate; penis; prevent; response; transmission process; vaccine development; vector

The primary goal of this Mucosal Biology Scientific Research Support Component (SRSC) is to identify antibody effector functions at mucosal surfaces required to prevent HIV-1 acquisition, define how they differ by route of transmission, and through integrated studies across SRSCs (Mucosal, Vector, Non-human Primate) determine modes of protective antibody induction in non-human primates and in collaborative human clinical vaccine studies. Specific Aims Aim 1. To support CHAVI-ID by defining the functional nature of protective antibody responses at mucosal surfaces elicited in RV144 follow-on trials (RV306, RV328), in other HlV-1 vaccine trials (HVTN 204, 082, 076) and in the HVTN/CHAVI501 mosaic trial. Aim 2. To support CHAVI-ID by assessing the functional characteristics of protective antibodies at mucosal surfaces in NHP Core studies designed to determine optimal route/adjuvant combinations for the induction of mucosal immunity. Aim 3. To support CHAVI-ID by evaluating the functional characteristics of protective antibodies at mucosal surfaces in NHP and Vector SRSC studies designed to determine optimal vector strategies for the induction of mucosal immunity. Aim 4. To support CHAVI-ID by determining the impact of dimeric vs monomeric antibodies on mucosal acquisition.

该粘液生物学科学研究支持组件（SRSC）的主要目标是确定预防HIV-1感染所需的粘膜表面抗体效应子功能，确定它们在传播途径上的差异，并通过跨SRSC（粘液、载体、非人灵长类动物）的综合研究确定非人灵长类动物和协作人类临床疫苗研究中的保护性抗体诱导模式。 具体目标 目标1。通过定义在RV 144后续试验（RV 306、RV 328）、其他HIV-1疫苗试验（HVTN 204、082、076）和HVTN/CHAVI 501嵌合试验中引起的粘膜表面处的保护性抗体应答的功能性质来支持CHAVI-ID。 目标二。通过评估NHP核心研究中粘膜表面保护性抗体的功能特征来支持CHAVI-ID，该研究旨在确定诱导粘膜免疫的最佳途径/佐剂组合。 目标3.通过评价NHP和载体SRSC研究中粘膜表面保护性抗体的功能特征来支持CHAVI-ID，这些研究旨在确定诱导粘膜免疫的最佳载体策略。 目标4。通过确定二聚体与单体抗体对粘膜获取的影响来支持CHAVI-ID。