Duke Comp Cancer Inst. Core Support Grant

项目总结(见说明)： 杜克综合癌症研究所 赫伯特·K·莱利，医学博士，导演 最近重组的杜克综合癌症研究所(DCCI)负责作为杜克大学在癌症方面的所有活动的中心，未来必须监督杜克大学的所有癌症业务。作为最大生物医学研究所之一的矩阵中心，DCCI通过利用杜克大学的基础研究，36年来一直得到美国国家癌症研究所(NCI)的持续支持 该中心拥有卓越的临床肿瘤学研究优势，每年治疗5,581名新癌症患者，每年招募1,000多名患者参加治疗性临床试验，并通过国家肿瘤学研究资源的存在而得到加强，例如NCI资助的两个合作小组的数据和统计中心。DCCI的成员总数为285人，其中成员有 自2004年以来，癌症研究的重点日益突出，NCI的资助额不断增加。为计划成员提供的资金总额为331,617,013美元，其中269,525,804美元来自同行评议来源。NCI、美国癌症协会或美国癌症协会资助的77,785,582美元或23.5%说明了癌症的焦点 国防部。从2004年到2008年，项目成员在PubMed引用的同行评议期刊上发表了6941篇论文。在这些出版物中，10%是方案内协作的结果，19%是方案间协作的结果。在此竞争性续订申请中，我们请求支持 我们在由17个共享资源支持的11个研究项目中的成员资格。DCCI成员取得了重大的科学进步，包括：开发创新的基因组测试以预测哪些癌症患者对特定的化疗有反应，以及对癌症和发育生物学中的关键信号通路的基本见解。DCCI负责监督杜克大学所有与癌症有关的慈善活动，这些基金 用于支持招募新成员、创新试点项目、支持多学科研究以及新的实验室和行政空间。这份对DCC持续支持的申请阐明了推动DCCI充分利用杜克大学和其他地方生物医学研究的巨大进步，以改善和延长癌症生命的原则、目标和战略 癌症患者和有癌症风险的患者，并向社会提供这些服务。

PROJECT SUMMARY (See instructions): Duke Comprehensive Cancer Institute Herbert K.Lyerly, M.D., Director The recently reorganized Duke Comprehensive Cancer Institute (DCCI) is charged to serve as the center of all Duke activities in cancer, with an imperative to oversee all of the Duke cancer operations in the future. As a matrix center in one of the largest biomedical research institutes, the DCCI has been continuously supported by the National Cancer Institute (NCI) for over 36 years, by leveraging Duke's basic research strengths with significant clinical oncology research excellence which is enabled by treating 5,581 new cancer patients annually, enrolling over 1,000 patients annually onto therapeutic clinical trials, and enhanced by the presence of national oncology research resources, such as the data and statistical centers of two NCI-funded cooperative groups. Total membership in the DCCI is 285 members, with members having an increasingly prominent focus in cancer research and increased amount of NCI funding since 2004. Total funding for program members is $331,617,013, of which $269,525,804 is from peer-reviewed sources. A cancer focus is illustrated by $77,785,582 or 23.5% of funding from the NCI, the American Cancer Society or the Department of Defense. From 2004-2008, program members published 6,941 papers in peer-reviewed journals cited in PubMed. Of these publications, 10% are the result of intra-programmatic collaborations and 19% due to inter-programmatic collaborations. In this competitive renewal application, we request support our membership in 11 Research Programs supported by 17 Shared Resources. DCCI members made significant scientific advances including: the development of innovative genomic tests to predict which cancer patients would respond to specific chemotherapy, and basic insight into critical signaling pathways in cancer and developmental biology. The DCCI oversees all cancer related philanthropy at Duke, and these funds have been used to support recruitment of new members, innovative pilot projects, support of multidisciplinary research, and new laboratory and administrative space. This application for ongoing support of the DCC articulates the principles, goals and strategies for propelling the DCCI to fully leverage the enormous advances in biomedical research at Duke and beyond, to improve and extend the lives of cancer patients with cancer and at risk for cancer, and delivering these to society.