Building social networks to achieve healthy weight gain during pregnancy

描述（由申请人提供）：拟议的研究和培训计划的目标是发展一个独立的转化研究事业，专注于预防儿童肥胖。Sabina Gesell博士的长期职业目标是在社会网络测量及其在传播健康行为方面的效用方面建立专业知识，目的是开发基于人群的干预措施，(1)针对与生命后期肥胖相关的人类发展关键窗口，(2)是可持续的。机构环境和对候选人的承诺是理想的：系主任，儿科学研究事务副主席，儿科学教师发展副主席都坚定地致力于她的成功，并提供必要的保护时间和方向，以实现本提案中概述的目标。部门主管和主要导师Shari Barkin博士承诺通过指导和资源积极支持她，以确保项目成功和职业发展成为一名富有成效的独立研究员。范德比尔特的CTSA基础设施开发成功的T2研究计划是无与伦比的。建议的职业发展计划侧重于通过(1)严格执行研究计划，(2)密集的研究指导，(3)高级课程，(4)独立学习，(5)教师研究研讨会和工作组，以及(6)全国会议，获得社会网络分析，现代纵向数据分析技术，成本效益分析，以及社区参与研究的伦理和方法方面的知识和高级技能。相关的研究项目是一个社会网络干预，旨在促进怀孕期间健康的体重增加。据估计，45%的美国女性在怀孕期间体重增加超过了医学研究所（IOM）的临床指南。妊娠期体重增加过多与妊娠期糖尿病、妊娠高血压、分娩并发症、婴儿巨大儿、儿童肥胖和产后持续的产妇肥胖有关。IOM和卫生保健研究与质量机构（AHRQ）都认为缺乏有效的妊娠期体重增加干预措施是一个主要的研究空白。本研究的目标是：(1)为拉丁裔女性提供一种文化定制的社会网络干预措施，以防止怀孕期间体重过度增加；(2)对120多名拉丁裔孕妇（e16岁）进行随机对照试验，检验这种社区干预对妊娠期体重增加的影响以及在IOM目标范围内体重增加的可能性；(3)检查怀孕期间健康的生活方式行为（营养、体育活动）通过新的社会关系传播的程度。这项研究将建立在该研究小组已经建立的信任和实质性社区关系的基础上，以及他们支持拟议方法的广泛初步研究。培训和研究将支持R01的成功。

DESCRIPTION (provided by applicant): The objective of the proposed research and training plan is to develop an independent translational research career focused on the prevention of pediatric obesity. Dr. Sabina Gesell's long-term career goal is to build an expertise in the measurement of social networks and their utility in spreading health behaviors with the purpose of developing population-based interventions that (1) target critical windows of human development associated with obesity later in life, and (2) are sustainable. The institutional environment and commitment to the candidate are ideal: Department Chair, Vice Chair for Research Affairs in Pediatrics, and Vice Chair for Faculty Development in Pediatrics are all firmly committed to her success and providing the necessary protected time and direction to attain the goals outlined in this proposal. Division Director and Primary Mentor, Dr. Shari Barkin has committed to actively supporting her through mentoring and resources to ensure project success and career development into a productive independent researcher. Vanderbilt's CTSA infrastructure to develop a successful T2 research program is unparalleled. The proposed career development plan is focused on gaining knowledge and advanced skills in social network analysis, modern longitudinal data analytic techniques, cost-effectiveness analyses, and ethics and methods of community-engaged research through (1) rigorous conduct of the research plan, (2) intensive research mentorship, (3) advanced coursework, (4) independent study, (5) faculty research seminars and working groups, and (6) national meetings. The associated research project is a social network intervention designed to facilitate healthy weight gain during pregnancy. It is estimated that 45% of US women gain in excess of the Institute of Medicine (IOM) clinical guidelines for weight gain during pregnancy. Excessive gestational weight gain is associated with gestational diabetes mellitus, pregnancy-related hypertension, complications through labor and delivery, infant macrosomia, childhood obesity, and persistent maternal obesity postpartum. Both the IOM and the Agency for Healthcare Research and Quality (AHRQ) have identified the lack of effective gestational weight gain interventions as a major research gap. The goals of the proposed research project are (1) To refine a culturally-tailored social network intervention for Latina women to prevent excessive weight gain during pregnancy; (2) To conduct a randomized controlled trial with more than 120 pregnant Latinas (e16 years old) to test the effect of this community-based intervention on gestational weight gain and likelihood of gaining within IOM target ranges; and (3) To examine the extent to which healthy lifestyle behaviors during pregnancy (nutrition, physical activity) are spread through new social ties. The study will build on the trust and substantive community relationships already developed by this research team, as well as their extensive preliminary research that supports the proposed approach. The training and research will support a successful R01.