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Cellular Events Underlying the Thrombocytopenia and Thrombosis in HIT

Cellular Events Underlying the Thrombocytopenia and Thrombosis in HIT
HIT 中血小板减少症和血栓形成背后的细胞事件
批准号：
8400935
负责人：
Mortimer Poncz
金额：
$33.98万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
项目状态：
已结题
起止时间：
2012-09-01 至 2017-06-30
来源：
https://reporter.nih.gov/project-details/8400935
关键词：
AffinityAntibodiesAntibody ActivationBindingBlood PlateletsCellsClinicalCollaborationsComplexDataDevelopmentDiagnosisDiagnostic testsDiseaseEndotheliumEquilibriumEventGAG GeneGenerationsHeparinHeparin BindingHumanImmuneImmune responseIn VitroInjuryInterventionLeadLeukocytesMediatingMicrofluidicsModelingMusNatureParticipantPassive ImmunizationPathogenesisPlatelet ActivationPlatelet Factor 4RiskRisk AssessmentRisk MarkerSiteSurfaceSystemTestingTherapeutic InterventionThrombinThrombocytopeniaThrombosisThrombusbasehuman SYK proteinin vitro Modelin vivoinsightmonocytenovel

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中文摘要
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英文摘要
Anti-platelet factor 4 (PF4)/heparin antibodies (Abs) and activation of platelet FcyRlla are involved in the pathogenesis of heparin-induced thrombocytopenia (HIT). However, the actual basis of the observed thrombocytopenia and thrombosis are not well understood, and markers of risk or diagnosis and targeted therapies remain limited. This Project focuses on furthering our understanding of the cellular events underiying the thrombocytopenia and thrombosis in HIT. We believe that platelets, leukocytes and endothelium, and derived microparticles (MP) contribute to both the thrombocytopenia and thrombosis. In this Project, we propose three novel interrelated cellular mechanisms that underiie the thrombocytopenia and prothrombotic nature of HIT:
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