Training in Congenital & Acquired Heart Disease

描述（由申请人提供）： 这个联合俄亥俄州州立大学（OSU）-全国儿童医院（NCH）机构T32博士后计划的目标是提供跨学科，翻译和国家的最先进的先天性和获得性心脏病的研究培训。该计划提供了一个独特的机会，专注于从出生到衰老的先天性和获得性心脏病的连续性，并比较这些不同人群之间的疾病机制和结果。其基本原理是，心脏病治疗和预防方面的进展最有可能源于促进医生科学家和基础科学家之间合作的转化研究计划。为了解决总体主题，我们将保持和扩大正在进行的努力，以提供一个学术环境，培养真正的“双向”转化研究，使我们的临床科学家确定的重大临床问题可以在实验室中得到解决，在实验室的关键发现可以迅速转化为更大的动物研究，并最终回到床边。 这个新的应用程序寻求每年5名学员，为期5年，承诺2年。研究员将从MD，DVM或博士候选人中选出，他们对心血管研究有浓厚的兴趣，并致力于疾病导向的研究事业。项目主任在心血管转化研究方面有着良好的记录，并将担任各自机构的主要负责人。培训计划设计包括正式的学术课程，研讨会和期刊俱乐部，为学员提供心脏病的概述和深入的心脏研究方向。学员将参加一个量身定制的“生存技能”课程，其中包括与专业发展有关的各种单元和讲习班。每个学员将在导师的实验室进行独立的研究项目。由20个校外资助的基础和临床科学导师和22个参与教师所涵盖的研究领域由他们与NCH心脏中心和OSU戴维斯心肺研究所的个人联系代表。将使用一个跨机构的网络系统对受训人员和导师进行评价。

DESCRIPTION (provided by applicant): The objective of this joint Ohio State University (OSU)-Nationwide Children's Hospital (NCH) institutional T32 postdoctoral program is to provide interdisciplinary, translational and state-of-the-art research training in congenital and acquired heart disease. This plan provides a unique opportunity to focus on a continuum of congenital and acquired heart disease from birth to senescence and to compare disease mechanisms and outcomes between these diverse population. The rationale is that advances in heart disease therapy and prevention are most likely to originate from a translational research program that fosters collaboration between physician-scientists and basic scientists. To address the overall theme, we will maintain and expand ongoing efforts to provide an academic environment to cultivate true 'bidirectional' translational research, so that significant clinical problems identified by our clinician scientists can be addressed in the laboratory, and key findings at the bench can be rapidly translated to larger animal studies and eventually back to the bedside. This new application seeks 5 trainees per year for 5 years with a 2-year commitment. Fellows will be selected from MD, DVM or PhD candidates who have strong interests in cardiovascular research and are committed to careers in disease-oriented investigations. The Program Directors have a strong-track record in translational cardiovascular research and will serve as the primary directors at their respective institutions. The training plan design consists of formal academic courses, seminars and journal clubs to provide trainees with an overview of heart disease and an in-depth cardiac research orientation. Trainees will participate in a tailor-made "survival skills" course comprised of various modules and workshops related to professional development. Each trainee will perform independent research projects in a mentor's laboratory. The research areas encompassed by the 20 extramurally funded basic- and clinical-science mentors and 22 participating faculty are represented by their individual affiliations with The Heart Center at NCH and The Davis Heart and Lung Institute at OSU. A cross-institution, web-based system will be used to perform trainee and mentor evaluations.