International Core

国际核心

• 批准号: 8531846
• 负责人: Gail E HENDERSON
• 金额: $ 12.63万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531846
• 关键词: AIDS clinical trial group; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Affect; Africa; Applications Grants; Area; Attention; Award; Behavioral Research; Bioethics; Biological; Breathing; Central America; China; Clinical; Clinical Trials Unit; Collaborations; Consultations; Country; Databases; Democratic Republic of the Congo; Development; Epidemic; Ethics; Faculty; Fostering; Funding; Government; Grant; Guatemala; HIV; HIV Vaccine Trials Network; HIV vaccine; Human Resources; IMPAACT; Immunology; Industry; Institutional Review Boards; Instruction; International; Investigator-Initiated Research; Investments; Laboratories; Leadership; Malawi; Manuscripts; Medical; Mentors; Mentorship; Microbicide Trials Network; Nicaragua; Play; Postdoctoral Fellow; Preparation; Prevalence; Prevention; Process; Protocols documentation; Public Health; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Training; Role; Russia; Services; Site; South Africa; Specimen; Speed; Students; Training; Training Programs; Translating; United States; United States National Institutes of Health; Work; abstracting; anticancer research; base; behavioral/social science; clinical care; clinical infrastructure; cohort; density; design; improved; interest; pre-doctoral; programs; protocol development; repository; research and development; social; social science research; success; transmission process; working group

The International Core is designed specifically to support the international research base of UNC, FHl, and RTI, including collaborating in-country investigators, foster synergy across the Cores and CFARs, and enhance HIV/AIDS research collaborations in key countries: Malawi, South Africa, the Democratic Republic of Congo (DRC), China, Russia, and in Central America, Nicaragua and Guatemala. The sheer volume and density of HIV in our collaborating sites allows research questions to be addressed with speed and efficiency impossible in places with lower HIV prevalence. A substantial part ofthe UNC CFAR's NIH support for HIV research comes for work undertaken outside the United States. This has involved leadership roles in the nternational NIH networks, including HPTN, the International ACTG, the CHAVI (Center for HIV Vaccine Immunology), Microbicide Trials Network and IMPAACT. UNC's global AIDS programs have led to the formation of an NIH HIV Clinical Trials Unit (CTU) in Lilongwe, Malawi, widely viewed as one ofthe best and most productive in the NIH Networks. Investigator-initiated research on HIV clinical care and biological and social factors related to HIV transmission and prevention of transmission is ongoing in Malawi, South Africa, China, the DRC, and Russia; research devoted to STD and HIV overlap has been a focus in China. UNC investigators have participated in virtually all Fogarty research Training Programs including AITRP, the Fogarty Center for Bioethics in Francophone Africa, the ICORTA-TB/AIDS, and the Fogarty Ellison pre- and post-doctoral programs. The Core provides: support for basic, clinical, and behavioral/social science infrastructure and capacity building; training in-country and at UNC in protocol development, IRB, and regulatory; and consideration of a range of ethical challenges raised by international research collaborations. The Core has provided leadership in facilitating cross-Core collaborations, mentoring junior investigators, manuscript and grant preparation for international collaborators, and communicating results from international research.

国际核心是专门设计来支持国际研究基地，FHI， RTI，包括合作的国内调查员，促进核心和CFAR之间的协同作用， 加强关键国家的艾滋病毒/艾滋病研究合作：马拉维、南非、民主共和国 刚果、中国、俄罗斯以及中美洲的尼加拉瓜和危地马拉。巨大的体积和 在我们的合作地点，艾滋病毒的密度使研究问题得到快速和有效的解决 在艾滋病毒感染率较低的地方是不可能的。美国国家卫生研究院对艾滋病的支持 研究是在美国境外进行的。这涉及到领导作用， 国际NIH网络，包括HPTN、国际ACTG、CHAVI（HIV疫苗中心 免疫学），杀微生物剂试验网络和IMPAACT。联合国的全球艾滋病项目已经导致 在马拉维的利隆圭成立了NIH HIV临床试验单位（CTU），被广泛认为是最好的， 在NIH网络中最具生产力。由调查人员发起的关于艾滋病毒临床护理和生物及 与艾滋病毒传播和预防传播有关的社会因素正在马拉维、南非 中国、刚果民主共和国和俄罗斯;致力于性病和艾滋病重叠的研究一直是中国的重点。UNC 调查人员几乎参加了所有福格蒂研究培训计划，包括AITRP， Fogarty非洲法语国家生物伦理学中心，ICORTA结核病/艾滋病，以及Fogarty Ellison预防和治疗中心。 博士后项目。核心提供：支持基础，临床和行为/社会科学 基础设施和能力建设;在方案制定、IRB和 监管;以及考虑国际研究合作提出的一系列伦理挑战。 核心在促进跨核心协作、指导初级调查员、 为国际合作者准备手稿和赠款，并交流来自 国际研究。