Large Scale T Cell Epitope Discovery for Burkholderia pseudomallei

类鼻疽伯克霍尔德氏菌大规模 T 细胞表位发现

• 批准号: 8709937
• 负责人: DANIEL ALTMANN
• 金额: $ 113.37万
• 依托单位: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8709937
• 关键词: Antigens; Australia; Bacteria; Binding; Biological Warfare; Bioterrorism; Burkholderia pseudomallei; Categories; Cells; Clinical; Complex; Detection; Diagnostic; Disease; Emerging Communicable Diseases; Endemic Diseases; Epitopes; Generations; Goals; Immune; Immunity; Infection; Life; Ligands; Maintenance; Melioidosis; Pathogenesis; Patients; Peptide/MHC Complex; Prevention; Role; Southeastern Asia; Staining method; Stains; T-Cell Activation; T-Lymphocyte; T-Lymphocyte Epitopes; Thailand; Therapeutic; Toxin; Transgenic Mice; Vaccines; Validation; base; cytokine; design; enzyme linked immunospot assay; improved; microorganism; novel; programs; response; tool; vaccine development

The goal of the Large Scale T Cell Epitope Discovery program is to establish and support several highly interactive, multi-disciplinary teams focused on large scale discovery of T cell epitopes associated with microorganisms responsible for emerging and re-emerging infectious diseases and potential agents of bioterrorism and their toxins. The discovery and validation of novel T cell epitopes will facilitate the design and development of vaccines; improved immune-based therapeutics; and diagnostic tools for the prevention, treatment and detection of such infections, by providing critical information needed to select MHC-peptide or other MHC-ligand complexes that induce T cell activation for the generation and maintenance of protective immunity.

大规模T细胞表位发现计划的目标是建立和支持几个高度互动的多学科团队，专注于大规模发现与新出现和重新出现的传染病和生物恐怖主义及其毒素的潜在代理人相关的T细胞表位。新T细胞表位的发现和验证将通过提供选择诱导T细胞活化以产生和维持保护性免疫的MHC-肽或其他MHC-配体复合物所需的关键信息，促进疫苗的设计和开发;改进的基于免疫的治疗剂;以及用于预防、治疗和检测此类感染的诊断工具。