Comparative Oncology

加州大学戴维斯分校癌症中心的比较肿瘤学项目专注于动物癌症生物学的几个特定方面。第一个主要主题是肿瘤生物学，主要研究致癌基因，肿瘤抑制基因。癌症干细胞和炎症-癌症。第二个主要主题。基因定义的癌症动物模型，是利用转基因和敲除动物模型来阐明肿瘤发生和进展的基本机制。第三个主题是大型动物的自发性癌症，使用非啮齿动物研究肿瘤发展，并在临床前环境中研究新的诊断和治疗方法。该计划为临床前设置带来了独特的技能和模型组合。它提供了实验室和病床之间的关键联系。项目目标是：(1)利用体外系统和体内癌症遗传定义的动物模型，研究癌基因和肿瘤抑制基因的信号通路以及炎症和癌症干细胞在肿瘤发生中的作用；(2)在动物模型中描述基因诱导的肿瘤发生，并开发新的动物模型和实验方法；(3)描述大型动物的自发性癌症特征，并对新的诊断和治疗方法进行临床前评估；(4)与其他项目合作，促进转化研究。该项目有29名成员，来自加州大学戴维斯分校的10个不同部门和3个学院。它有17个NCl资助的项目，资助金额为260万艺康（同行评审资助总额为1140万艺康）。该小组在上一个资助期内有524份出版物；21%是方案间的，10%是方案内的。

The Comparative Oncology Program of the University of California, Davis Cancer Center focuses on several specific aspects of cancer biology in animals. The first major theme, Tumor Biology, is the study of major Oncogenes, Tumor Suppressor genes. Cancer Stem Cells and Inflammation-Cancer. The second major theme. Genetically Defined Animal Models of Cancer, is the study of tumor development and progression employing transgenic and knockout animal models to elucidate basic mechanisms. The third major theme, Spontaneous Cancers in Large Animals, uses non-rodent animals to study tumor development and investigate novel diagnostics and therapeutics in a preclinical setting. This program brings a unique combination of skills and models to the preclinical setting. It provides the critical links between bench and bedside. The programmatic goals are: (1) to examine the signaling pathways of oncogenes and tumor suppressor genes and the role of inflammation and cancer stem cells in tumorigenesis using both in vitro systems and genetically defined animal models of cancer in vivo; (2) to characterize genetically induced tumorigenesis in animal models and development of novel animal models and experimental approaches; (3) to characterize spontaneous cancers in large animals and to perform preclinical evaluation of novel diagnostics and therapeutics; and (4) collaboration with other programs to facilitate translational research. The program has 29 members from ten different departments and three schools at UC Davis. It has 17 NCl funded projects for $2.6 million ADC (total peer-reviewed funding, $11.4 million ADC). The group has 524 publications for the last funding period; 21% are inter-programmatic and 10% are intra-programmatic.