Biotechnology Training in Biomedical Sciences and Engineering

生物医学科学与工程生物技术培训

• 批准号: 8496815
• 负责人: Yi Tang
• 金额: $ 20.19万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496815
• 关键词: Biotechnology; Engineering; Science; Training

DESCRIPTION (provided by applicant): The goal of the UCLA Biotechnology Training in Biomedical Science and Engineering (BTBSE) Program is to educate and to train the next generation of highly skilled scientists and engineers who will assume leadership roles in multidisciplinary biotechnology research. This goal is achieved through a cohesive 2-year training program entailing multidisciplinary research, a common curriculum composed of formal coursework in life science and engineering and of a cross-disciplinary laboratory rotation, and an industrial internship. The required coursework is comprised of a course in macromolecular synthesis and structure, a course on molecular biotechnology from an engineer's perspective, the "Biotechnology Forum" course, and a class in research ethics. Life science trainees must work in the research laboratory of an engineering mentor for at least three months; likewise the engineers spend time in the laboratory of their life science mentor. A biotechnology community is fostered principally through the monthly trainee lunch seminar series and the Annual Biotechnology Symposium, which brings together ~50 students, faculty and industry representatives and is currently in its fourth successful installment. Trainees who complete this program will be equipped to function productively in the multidisciplinary teams of bioengineers and life scientists prevalent in the industry. The interface between the life/health sciences and engineering is extraordinarily rich in its diversity, and this biotechnology program focuses broadly on molecular and cellular research. Faculty participants in the proposed BTBSE Program all mentor PhD students who conduct research focused at the molecular and cellular level, and most have established cross-disciplinary collaborations. The faculty research activities cover a broad spectrum of basic biomedical research related to biotechnology including, enzyme biocatalysis, thermostable enzymes, metabolic engineering, DNA microarray technology, nitric oxide metabolism, molecular basis of neurodegenerative disease, biosensors, tissue engineering, anaerobe microbiology, vaults (protein nanocapsules), nanobiotechnology, bioinformatics, genomics, proteomics, protein molecular evolution, and incorporation of unnatural amino acids in recombinant proteins. Such an array of research activities conducted by collaborating researchers provides an exciting menu of multidisciplinary research opportunities to trainees. Faculty participants in the proposed training program have had the opportunity to recruit from a pool of 127 eligible PhD students (including 13 underrepresented minority students) this academic year. The Director and faculty mentors are very active and successful in underrepresented minority student development and recruitment, especially from the very diverse, populous greater Los Angeles area. It is planned to grow the program over the next several years to a trainee graduation rate of 6/year (12 in training/yr). In sum, UCLA provides the talented multidisciplinary faculty, bright and diverse students, resources for research, courses, and opportunities to interact with industry that are necessary to mount a successful biotechnology training program.

描述（由申请人提供）：加州大学洛杉矶分校生物医学科学与工程（BTBSE）计划生物技术培训的目标是教育和培训下一代高技能的科学家和工程师，他们将在多学科生物技术研究中发挥领导作用。这一目标是通过一个有凝聚力的为期2年的培训计划来实现的，该计划需要多学科研究、由生命科学和工程正式课程、跨学科实验室轮换和工业实习组成的通用课程。必修课程包括大分子合成和结构课程、从工程师角度看分子生物技术课程、“生物技术论坛”课程和研究伦理课程。生命科学实习生必须在工程导师的研究实验室工作至少三个月;同样，工程师也要在生命科学导师的实验室工作。生物技术社区主要通过每月的实习生午餐研讨会系列和年度生物技术研讨会来培养，该研讨会汇集了约50名学生，教师和行业代表，目前正在第四次成功举办。完成该项目的学员将能够在该行业普遍存在的生物工程师和生命科学家的多学科团队中发挥有效作用。生命/健康科学和工程之间的接口是非常丰富的多样性，这个生物技术计划主要集中在分子和细胞研究。参与拟议的BTBSE计划的教师都指导博士生谁进行研究集中在分子和细胞水平，大多数已经建立了跨学科的合作。教师的研究活动涵盖了与生物技术相关的广泛的基础生物医学研究，包括酶生物催化，耐热酶，代谢工程，DNA微阵列技术，一氧化氮代谢，神经退行性疾病的分子基础，生物传感器，组织工程，厌氧菌微生物学，拱顶（蛋白质纳米胶囊）、纳米生物技术、生物信息学、基因组学、蛋白质组学、蛋白质分子进化和在重组蛋白中掺入非天然氨基酸。由合作研究人员进行的一系列研究活动为学员提供了令人兴奋的多学科研究机会。参与拟议培训计划的教师有机会从本学年127名合格的博士生（包括13名代表性不足的少数民族学生）中招募。主任和教师导师是非常积极和成功的代表性不足的少数民族学生的发展和招聘，特别是从非常多样化，人口众多的大洛杉矶地区。计划在未来几年内将该方案扩大到每年6名学员的毕业率（每年培训12名学员）。总之，加州大学洛杉矶分校提供了有才华的多学科教师，聪明和多样化的学生，研究资源，课程和机会，与行业互动，这是必要的安装一个成功的生物技术培训计划。