Mass Spectroscopy Core

质谱核心设施提供支持，使传统和非传统的质谱用户能够应用先进的小分子质谱分析来实现他们的研究目标。该核心的主要重点是小分子分析，包括代谢组学、脂质组学、药物代谢、分子结构鉴定和小分子定量。根据IDeA资助的核心实验室数据库，在列出的63个质谱核心设施中，只有7个提供小分子分析服务，只有4个允许脂质组学分析。我们对小分子的小分子质谱分析的相对独特性导致了最近对我们服务的需求激增，手稿出版的急剧增加，以及提交和收到资助的增加。该质谱核心设施的主要作用是：(1)为使用已建立的小分子质谱分析方法提供设施；(2)积极开发新的质谱方法用于小分子分析，以及数据收集和分析；(3)不断扩大我们的能力，以支持新的研究项目；(4)为研究生提供质谱方面的高级培训；(5)协助招聘新教师；(6)协助校外调查人员进行类似的分析。本核心的运作基于核心网站上公布的经批准的政策，这些政策规范了所提供的服务、工具的获取、培训、质量控制、成本和冲突解决。目前，我们主要提供两类服务：(1)全方位服务，核心人员执行分析和培训调查人员进行样品提取和制备；和(2)。自助服务，核心人员培训调查员进行自己的样品提取，制备和分析。我们的顾问委员会就这些政策和活动提供意见。COBRE质谱仪核心设施的第三期支持将使我们能够支持现有和未来的研究项目，将增强我们的可持续性，并将大大促进中部地区及其他地区生物医学研究的发展。

The Mass Spectrometry Core Facility provides support to enable traditional and non-traditional users of mass spectrometry the ability to apply advanced mass spectrometry analysis of small molecules to achieve their research objectives. The major focus of this Core is small molecule analysis including metabolomics, lipidomics, drug metabolism, molecule structure identification, and small molecule quantification. According to the Network of IDeA Funded Core Laboratories database, out of 63 mass spectrometry core facilities listed, only seven (7) provide small molecule analysis service, and just four (4) allow for lipidomic analysis. The relative uniqueness of our small molecule mass spectrometry analysis of small molecules has resulted in a recent surge in demand for our services, a dramatic increase in the publication of manuscripts, and an increase in submission and receipt of funded grants. The major roles of this Mass Spectrometry Core Facility are to: (1) Provide a facility for the use of established methods of mass spectroscopic analysis of small molecules; (2) Actively develop new mass spectrometry approaches for small molecule analysis, as well as data collection and analysis; (3) Continuously expand our capacity and capabilities to support new research projects; (4) Provide advanced training in mass spectrometry especially to graduate students; (5) Assist with new faculty hiring; and (6) Aid off-campus investigators with similar analyses. The operation of this Core is based on approved policies posted on the Core's website that regulate services provided, access to the instruments, training, quality control, cost, and conflict resolution. Currently, we are providing two major types of services: (1.) Full service where Core personnel perform the analyses and train investigators for sample extraction and preparation; and (2.) Self service where Core personnel train investigators to perform their own sample extraction, preparation and analysis. Our advisory board provides input on these policies and activities. COBRE Phase III support of the Mass Spectrometry Core Facility will enable us to support existing and future research projects, will enhance our sustainability, and will significantly facilitate the development of biomedical research in the Central Region and beyond.