HIV感染者滥用甲基苯丙胺神经毒性增强的因素-猫眼课题宝

HIV感染者滥用甲基苯丙胺神经毒性增强的因素

批准号：

8417730

负责人：

LINDA CHANG

金额：

$41.42万

依托单位：

UNIVERSITY OF HAWAII AT MANOA

依托单位国家：

美国

项目类别：

财政年份：

2010

资助国家：

美国

项目状态：

已结题

起止时间：

2010-03-01 至 2015-01-31

来源：

https://reporter.nih.gov/project-details/8417730

关键词：

AIDS neuropathy Abbreviations Acquired Immunodeficiency Syndrome Advisory Committees Amino Acids Animals Antidotes Antioxidants Brain Brain Diseases Brain region Carrier Proteins Cell model Cells Clinical Committee Members Complement DNA Nucleotidylexotransferase Development Dietary Selenium Dopamine Drug abuse Equilibrium Excitatory Postsynaptic Potentials Faculty Family Genetic Glucosephosphate Dehydrogenase Glutathione Guanine HIV Hawaii Hawaiian population Health Heavy Metals Human Hydrogen Peroxide Hypoxanthines Impaired cognition Infection Institution Instruction Intake Iodide Peroxidase Knock-out Knockout Mice Label Lead Learning Letters Life Long-Term Potentiation Malnutrition Memory Mentorship Methamphetamine Micronutrients Mood Disorders Movement Mus National Institute of Drug Abuse Native Hawaiian or Other Pacific Islander Needles Neuraxis Neuronal Injury Neurotoxins Nitric Oxide Organ Oxidants Oxidation-Reduction Oxidative Stress Peroxonitrite Persons Population Predisposition Property Proteins Quantitative Reverse Transcriptase PCR Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Reverse Transcriptase Polymerase Chain Reaction Rodent Model Role Scientist Selenium Selenocysteine Signal Transduction Students Supplementation Surveys System Toxic effect Training Transactivation Translational Research United States Universities Viral Virus Diseases aged career development developmental disease dopamine toxicity dopamine transporter dopaminergic neuron enhancing factor glutathione peroxidase graduate student health disparity high risk sexual behavior insight intraperitoneal member methamphetamine abuse methamphetamine exposure monoamine nervous system disorder neuronal survival neuroprotection neurotoxicity non-drug prevent programs public health relevance response reuptake selenium deficiency selenoenzyme selenophosphate synthetase selenoprotein small hairpin RNA thioredoxin reductase web site

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DESCRIPTION (provided by applicant): This application is submitted in response to PAR-09-011 Diversity-promoting Institutions Drug Abuse Research Program (DIDARP) requested by the National Institute on Drug Abuse (NIDA). This proposed research program is timely since it focuses on two ofthe major health disparity issues in Hawaii, namely, methamphetamine abuse and HIV infection. Recent surveys indicate that Native Hawaiians or other Pacific islanders have the highest rate of methamphetamine use among persons aged 12 or older in the United States. Although HIV/AIDS infection rate is relatively low in Hawaii compared to other major metropolis, the rates are increasing among Hawaiians. This DIDARP will include two primary and one pilot research projects that will focus on mechanisms and factors that might enhance neurotoxicity associated with methamphetamine of HIV. We aim to enhance the capacity for drug abuse research at UH by creating this small translational research team. This group will take advantage and build on the expertise of the few but outstanding existing clinical drug abuse and HIV researchers and basic scientists. We aim to enable UH to develop a strong clinical and translational drug abuse research program. To complement these projects, we additionally propose training and career development activities that wil offer exciting opportunities for DIDARP investigators and others at UH through the Administrative and Training Core. The Faculty in the Core will provide guidance and mentorship for these junior faculty and graduate students, through infrastructure support, educational courses, seminars, and a dedicated DIDARP website, We have obtained institutional support for two additional graduate students for the program. We also have recruited 4 distinguished External Advisory Committee members with expertise related to the proposed research; each has enthusiastically agreed to provide their advice and letter of support for the development of this DIDARP at UH.

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