The Utah Regional Network for Excellence in Neuroscience Clinical Trials

描述（由申请人提供）：尽管有无与伦比的机会来评估常见和罕见神经系统疾病的新疗法，但参与多中心临床试验的研究人员在有效设计、支持和执行这些试验方面面临着越来越多的挑战。神经科学临床试验卓越网络（NEXT）旨在帮助解决这一日益复杂的环境，并通过创建支持高质量站点和协调中心的国家化网络的集中式基础设施，促进多中心神经科学试验的高效稳健机制。位于犹他大学的犹他州神经科学临床试验卓越区域网络（UR-NEXT）将为协调西部山间5州地区的招募和准入提供理想的机制。在儿科和成人临床研究和试验方面具有合作记录和经验的领导团队以及经验丰富的临床试验经理的协调努力将确保在广泛的疾病中进行高质量的神经科学试验。uh - next将以犹他大学为中心，犹他大学与临床神经科学中心（5个州地区唯一的综合神经科学中心）、盐湖城退伍军人管理医疗中心（落基山脉地区的西部支柱）和初级儿童医疗中心（PCMC）（该地区领先的儿科转诊中心）之间存在着长期密切的合作关系。西部山间神经学组织（WINO）的成员范围从犹他州南部到蒙大拿州，从内华达州到科罗拉多州西部，已建立的对临床试验感兴趣的转诊社区神经学家网络也将使u - next受益。神经内科在每一个主要专科都设有分部，在成人和儿童多中心临床试验的管理和表现方面拥有丰富的专业知识。UR-NEXT将受益于临床和转化科学中心以及许多其他合作资源。总的来说，该网络主要覆盖了大约800万人口，使其成为该地区NEXT站点的理想选择。

DESCRIPTION (provided by applicant): In spite of unparalleled opportunities to assess novel therapies for both common and rare neurological disorders, investigators involved in multicenter clinical trials face an increasing array of challenges in efficiently designing, powering and performing such trials. The Network of Excellence in Neuroscience Clinical Trials (NEXT) is intended to help address this increasingly complex environment and facilitate an efficient robust mechanism for multicenter neuroscience trials via the creation of centralized infrastructure supporting a nationalized network of high quality sites and coordinating centers. Based at the University of Utah, the Utah Regional Network for Excellence in Neuroscience Clinical Trials (UR-NEXT) will provide an ideal mechanism for coordinating recruitment and access throughout a 5 state region in the Intermountain West. The coordinated efforts of a leadership team with a track record of collaboration and experience in both pediatric and adult clinical studies and trial and an experienced clinical trials manager will ensure the performance of high quality neuroscience trials across a broad range of diseases. The UR-NEXT will be centered at the University of Utah, where longstanding and close partnerships exist between the Clinical Neuroscience Center, the only integrated neuroscience center in a 5 state region, the Salt Lake City Veteran's Administration Medical Center, the western anchor for the Rocky Mountain Region, and Primary Children's Medical Center (PCMC), the leading pediatric referral center for the region. UR-NEXT will additionally benefit from an established network of referring community neurologists with interest in clinical trials, the Western Intermountain Neurological Organization (WINO), which has members ranging from southern Utah to Montana, and Nevada to western Colorado. The Neurology Department has sections in each major subspecialty and substantial expertise in the management and performance of both adult and pediatric multicenter clinical trials. The UR-NEXT will benefit from the Center for Clinical and Translational Science as well as numerous other collaborative resources. Overall, the network has primary access to a population of approximately 8 million covered lives, making it the ideal choice for a NEXT site for this region.