The Utah Regional Network for Excellence in Neuroscience Clinical Trials

描述(由申请人提供)：尽管评估常见和罕见神经疾病的新疗法有无与伦比的机会，但参与多中心临床试验的研究人员在有效设计、驱动和执行此类试验方面面临着越来越多的挑战。神经科学临床试验卓越网络(NEXT)旨在帮助解决这一日益复杂的环境，并通过创建支持由高质量站点和协调中心组成的全国性网络的集中式基础设施，为多中心神经科学试验促进高效可靠的机制。犹他州神经科学临床试验卓越地区网络(UR-NEXT)总部设在犹他州大学，将为协调西部山区5个州地区的招募和入学提供理想的机制。在儿科和成人临床研究和试验方面拥有合作和经验记录的领导团队以及经验丰富的临床试验经理的协调努力将确保在各种疾病中进行高质量的神经科学试验。UR-NEXT将集中在犹他大学，临床神经科学中心是5个州地区唯一的综合神经科学中心，盐湖城退伍军人管理医疗中心是落基山地区的西部支柱，初级儿童医疗中心(PCMC)是该地区领先的儿科转诊中心，该大学与临床神经科学中心建立了长期密切的合作伙伴关系。UR-NEXT还将受益于已建立的对临床试验感兴趣的社区神经学家推荐网络，即西部山间神经组织(WINO)，其成员范围从犹他州南部到蒙大拿州，从内华达州到科罗拉多州西部。在成人和儿科多中心临床试验的管理和执行方面，神经科在每个主要分科都有部门和丰富的专业知识。UR-NEXT将受益于临床和转译科学中心以及许多其他合作资源。总体而言，该网络主要接触到约800万覆盖生活的人口，使其成为该地区下一个地点的理想选择。

DESCRIPTION (provided by applicant): In spite of unparalleled opportunities to assess novel therapies for both common and rare neurological disorders, investigators involved in multicenter clinical trials face an increasing array of challenges in efficiently designing, powering and performing such trials. The Network of Excellence in Neuroscience Clinical Trials (NEXT) is intended to help address this increasingly complex environment and facilitate an efficient robust mechanism for multicenter neuroscience trials via the creation of centralized infrastructure supporting a nationalized network of high quality sites and coordinating centers. Based at the University of Utah, the Utah Regional Network for Excellence in Neuroscience Clinical Trials (UR-NEXT) will provide an ideal mechanism for coordinating recruitment and access throughout a 5 state region in the Intermountain West. The coordinated efforts of a leadership team with a track record of collaboration and experience in both pediatric and adult clinical studies and trial and an experienced clinical trials manager will ensure the performance of high quality neuroscience trials across a broad range of diseases. The UR-NEXT will be centered at the University of Utah, where longstanding and close partnerships exist between the Clinical Neuroscience Center, the only integrated neuroscience center in a 5 state region, the Salt Lake City Veteran's Administration Medical Center, the western anchor for the Rocky Mountain Region, and Primary Children's Medical Center (PCMC), the leading pediatric referral center for the region. UR-NEXT will additionally benefit from an established network of referring community neurologists with interest in clinical trials, the Western Intermountain Neurological Organization (WINO), which has members ranging from southern Utah to Montana, and Nevada to western Colorado. The Neurology Department has sections in each major subspecialty and substantial expertise in the management and performance of both adult and pediatric multicenter clinical trials. The UR-NEXT will benefit from the Center for Clinical and Translational Science as well as numerous other collaborative resources. Overall, the network has primary access to a population of approximately 8 million covered lives, making it the ideal choice for a NEXT site for this region.