University of Cincinnati NETT Network Hub and Spoke System

描述(由申请人提供)：神经急症治疗试验(NETT)网络已经成功地建立了一个包括急诊医生、神经学家和神经外科医生的临床研究网络。该网络的目标是通过执行NINDS赞助的临床试验(RFA-NS-06-002)，有效地为急性神经疾病患者开发更好的治疗方法。NETT网络的基本目标是加快临床试验的招募。大辛辛那提/北肯塔基州NETT中心和分支系统是2006年申请申请资助的17个原始临床站点中心之一。到目前为止，我们的辛辛那提NETT中心和分支系统已经招募了226名患者参加通过NETT网络进行的试验。这使我们成为NETT中心中注册人数第二多的公司。在这次续签申请中，我们建立在我们现有的中心和分支系统的成功基础上，有以下具体目标：#1)有效地招募和留住参与者，并在NETT试验中优化数据质量；#2)积极为NETT网络的整体成功做出贡献。为了实现这些目标，我们确定了有助于我们继续取得成功的四个关键因素。这些措施包括：强有力的和持续的机构和社区支持；接触到必须普及成果的人口的人口统计代表；不加过滤地获得各种急性神经疾病和损伤；以及积极参与和促进NETT网络的努力。在这份竞争性续签申请中，我们展示了我们中心主要参与者的强有力和坚定不移的支持，包括医学院院长和我们中心医院的首席执行官。此外，我们表现出强大的、多学科的承诺，致力于我们的中心和辐射系统的成功，体现在我们的咨询委员会成员中，包括神经内科和神经外科的主席、CTSA的PI、创伤科主任以及大辛辛那提一个大型卫生系统的首席运营官，该系统的职权范围包括我们的五家分支医院。除了我们从机构和社区领导人那里获得的高水平支持外，我们还通过提供相关疾病过程的数据并展示我们从医务主任到床边护士的坚定不移的支持来展示我们接触适当患者群体的能力。我们已经并将继续积极参与所有NETT网络活动，以了解我们如何继续优化我们的中心和分支系统，同时以可能对其他中心有益的方式分享我们的经验。

DESCRIPTION (provided by applicant): The Neurological Emergencies Treatment Trials (NETT) Network has successfully established a clinical research network including emergency physicians, neurologists and neurosurgeons. The network's goals are to efficiently develop better treatments for patients with acute neurological disorders through execution of NINDS-sponsored clinical trials (RFA-NS-06-002). The essential aim of the NETT Network is to expedite recruitment into clinical trials. The Greater Cincinnati/Northern Kentucky NETT Hub and Spoke System was one of seventeen original Clinical Site Hubs funded under the 2006 Request for Applications. To date, our Cincinnati NETT Hub and Spoke System has enrolled over 226 patients in trials being conducted through the NETT Network. This positions us as the 2nd highest enroller among NETT Hubs. In this renewal application, we build on the success of our existing Hub and Spoke System with the following specific aims: #1) Efficiently recruit and retain participants and optimize data quality in NETT trials; and, #2) Actively contribute to the overall success of the NETT Network. To achieve these aims, we have identified four key ingredients that contribute to our continued success. These include: strong and ongoing institutional and community support; access to a demographic representative of the populations to which results must be generalized; unfiltered access to the full spectrum of acute neurologic disease and injury; and, active participation in and contributory to the efforts of the NETT Network. In this competitive renewal application, we demonstrate the strong and unwavering support of key players at our Hub including the Dean of the College of Medicine and the CEO of our Hub hospital. Further, we show a strong, multidisciplinary commitment to the success of our Hub and Spoke System embodied in our Advisory Committee members which include the Chairmen of Neurology and Neurosurgery, the PI of our CTSA, the Director of the Division of Trauma, and the COO of a large health system in Greater Cincinnati whose purview includes five of our Spoke hospitals. In addition to the high level support we receive from Institutional an community leaders, we demonstrate our ability to access the appropriate patient populations by presenting data on the relevant disease processes and showing the unyielding support we have from 'boots-on-the-ground' personnel from Medical Directors to bedside nurses. We have and will continue to be actively engaged in all NETT Network activities in order to learn how we may continue to optimize our Hub and Spoke System while also sharing our experience in ways that may be beneficial to other Hubs.