2013 Molecular Pharmacology Gordon Research Conference and Gordon Research Semina

描述(由申请者提供)：分子药理学戈登研究会议(GRC)是一个重要的论坛，聚集了基础、应用和临床科学中的G蛋白偶联受体(GPCR)研究的科学家。在此，我们请求对2013年第24届GRC会议提供部分支持，该会议将包括GRC和最近参加的戈登会议研究研讨会(GRS)。GRC/GRS 2013年的具体目标旨在吸引学术界和工业界最优秀的科学家讨论该领域的重大发展，鼓励对该领域最新和有争议的想法进行公开讨论，促进翻译机会领域的合作，并为博士生、博士后和初级科学家提供一个高效的论坛，让他们与MOR高级同事分享他们的成果并进行互动。分子药理学GRC传统上在美国和欧洲之间轮流举行，GRC/GRS 2013将在托斯卡纳(Il Ciocco，意大利)举行。会议将重点关注该领域的新兴领域和快速发展领域。2013年计划的创新包括高度重视与生理学相关的机制，讨论不寻常的GPCR或模型系统，以及展示针对动物生物学和人类疾病的单分子的尖端方法。具体地说，该计划将涵盖四个主要领域：i)受体和受体复合体的结构动力学，包括单分子水平的研究；ii)细胞和体内的基于配体的信号转导；以及 (3)药物开发和治疗的新机会，包括确定与人类疾病有关的GPCRs和(4)孤儿和非典型GPCRs，揭示这些重要信号蛋白的新作用模式。方法学方面将包括新的物理和计算方法，创新的生物传感器和光控制过程的开发，以及新的治疗策略。这次会议将聚集大约150名演讲者和与会者，预期的结果是思想和技术的交叉融合，以加深对GPCR生物学和相关疾病的理解。

DESCRIPTION (provided by applicant): The Molecular Pharmacology Gordon Research Conference (GRC) is a key forum gathering scientists from basic, applied and clinical science in G protein coupled receptor (GPCR) research. Here we request partial support for the 2013 conference, 24th GRC edition, which will include both the GRC and the recently adjoined Gordon Conference Research Seminar (GRS). Specific aims of GRC/GRS 2013 seek to attract the very best scientists from academic and industrial worlds to discuss major developments in the field, encourage open discussions on latest and also controversial ideas in the field, facilitae collaborative work in areas of translational opportunities, and serve as a highly effective forum for doctoral students, post-docs and junior scientists to share their results and interact with mor senior colleagues. The Molecular Pharmacology GRC traditionally alternates between US and Europe, and the GRC/GRS 2013 will be held in Tuscany (Il Ciocco, Italy). The conference will emphasize both emerging and rapidly growing areas in the field. Innovation in the 2013 program includes a strong emphasis on mechanisms relevant to physiology, discussion on unusual GPCRs or model systems, and the presentation of cutting-edge methodologies addressing single molecules to animal biology and human diseases. Specifically the program will cover four main areas: i) structural dynamics of receptors and receptor complexes including studies at the single molecule level, ii) ligand-biased signaling in cellular and in vivo, and novel approaches to physiology with an emphasis on animal models, (iii) novel opportunities for drug development and therapeutics, including the identification of GPCRs linked to human diseases and (iv) orphan and atypical GPCRs, revealing new mode of action of these important signaling proteins. Methodological aspects will include novel physical and computing approaches, the development of innovative biosensors and light-controlled processes, and novel therapeutic strategies. The conference will gather about 150 speakers and attendees and the anticipated outcome is cross-fertilization of ideas and techniques, towards enhanced understanding of GPCR biology and associated diseases.