RESEARCH IN DEVELOPMENTAL ENDOCRINOLOGY AND METABOLISM

描述（由申请人提供）：波士顿儿童医院发育内分泌和代谢培训基金旨在为从事研究培训的博士后提供资金，从而在学术儿科内分泌学方面独立发展。学员从儿童医院高素质的儿科内分泌学研究员中挑选，以医学博士、医学博士/博士或偶尔的博士学位进入该项目。28名培训人员中，小儿内分泌内科医生13人（其中医学博士5人），其他学科内科医生13人，博士2人。儿童医院是主要的培训地点，还有马萨诸塞州总医院、贝斯以色列女执事医疗中心、布里格姆妇女医院和乔斯林糖尿病中心的实验室。这项培训补助金的主要研究重点包括糖尿病、肥胖症、神经内分泌学、甲状腺疾病、骨骼健康、干细胞生物学、生物信息学、离子转运和人类结果研究方面的临床、转化和基础实验室研究。培训包括教学课程，包括定量方法和研究的道德行为，以及个别指导研究的密集时期。预期的平均培训时间为两年。在过去10年中完成该培训计划的15名学员中，除1名外，其余均为儿科学术机构的教师（1名教授，2名助理教授，9名讲师），2名在工业界。其中3人获得了独立的NIH K奖，1人获得了R01。他们的出版记录很好。该项目利用了内分泌科培训教师的广泛科学专业知识，以及波士顿儿童医院社区和哈佛大学周边环境。

DESCRIPTION (provided by applicant): This training grant in developmental endocrinology and metabolism at Children's Hospital Boston intends to provide funding for postdoctoral fellows to engage in research training leading to independent careers in academic pediatric endocrinology. Trainees enter the program with either the MD, MD/PhD or occasionally the PhD degree, and are selected from highly qualified pediatric endocrinology fellows at Children's Hospital. The 28 trainers include 13 pediatric endocrine physician-scientists (including 5 MD/PhDs), 13 physician-scientists of other disciplines, and 2 PhD scientists. Children's Hospital is the major training site, along with laboratories at Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, and Joslin Diabetes Center. The major areas of research emphasis in this training grant include clinical, translational and basic laboratory research in diabetes mellitus, obesity, neuroendocrinology, thyroid disease, bone health, stem cell biology, bioinformatics, ion transport, and human outcomes research. Training consists of didactic courses, including in quantitative methods and the ethical conduct of research, and an intensive period of individually mentored research. The intended average duration of training is two years. Of the 15 trainees during the past 10 years who have completed this training program, all but 1 are faculty in academic pediatric institutions (1 Professor, 2 Assistant Professors, 9 Instructors) and 2 are in industry. Of these, 3 have had independent NIH K awards, and 1 has an R01. Their record of publication is strong. This program takes advantage of the breadth of scientific expertise of the training faculty within the Division of Endocrinology, as well as in the larger Children's Hospital Boston community and surrounding Harvard environment.