CANCER GENOMICS SHARED RESOURCE

项目总结（见说明）： 癌症基因组学共享资源（CGSR）将最先进的基因组仪器与杰出的技术专长相结合。Winship癌症研究所（Winship）的成员受益于在CLIA认证的环境中促进基础科学和转化研究的服务。这些服务由经验丰富的基因组学专业人员提供，他们确保所有仪器和 程序受到严格的质量控制。最近的关键设备采购强调了CGSR对癌症研究应用新技术和下一代测序的关注，包括llumina HiScan、Fluidigm Access Array和lon Torrent个人基因组机器。 CSGR通过癌症中心支持补助金（年度运营成本的5%）和Winship机构支持（年度运营成本的30%）的资助，能够保持服务的价格竞争力。 在过去的一年里，CGSR生成的基因表达和甲基化阵列数据为高影响力的出版物和成功的多研究者资助奖做出了贡献，包括NASA专门研究中心（PI：Ya Wang，博士）。随着新的领导和明确的战略举措，CGSR正在推进其在癌症诊断和疾病分类，风险分层和治疗决策中的作用。

PROJECT SUMMARY (See instmctions): The Cancer Genomics Shared Resource (CGSR) combines state-of-the-art genomic instrumentation with outstanding technical expertise. Members of the Winship Cancer Institute (Winship) benefit from services that facilitate basic science as well as translational research in a CLIA-certified environment. These services are delivered by experienced genomics professionals who ensure that all Instrumentation and procedures are rigorously quality controlled. Recent key equipment purchases underscore the CGSR's focus on new technologies and next generation sequencing for cancer research applications and include an llumina HiScan, Fluidigm Access Array, and lon Torrent Personal Genome Machine. The CSGR has been able to remain price-competitive for services through funding from the Cancer Center Support Grant (5% of annual operating costs) and Winship institutional support (30% of annual operating costs). In the past year, gene expression and methylation array data generated by the CGSR have contributed to high impact publications and successful multi-investigator grant awards including as NASA Specialized Center of Research (PI: Ya Wang, Ph.D.). With new leadership and well defined strategic initiatives, the CGSR is advancing its role in cancer diagnosis and disease classification, risk stratification, and therapeutic decision-making at the Winship Cancer Institute.