Gammacell 1000 Elite Self-Contained Blood Irradiator

描述（由申请人提供）：我们正在申请资金购买伽马辐照系统（Gammacell 1000 Elite, Best Theratronics），以支持美国国立卫生研究院资助的莫尔豪斯医学院(MSM)/亚特兰大大学中心（AUC）的基本健康差异相关研究。Gammacell 1000 Elite是一个使用铯源的独立伽马辐照器。该辐照器用于各种研究目的，包括但不限于：研究辐射引起的损伤、灭菌材料、选择特定细胞类型和抑制免疫反应。因此，它是生物医学研究不可或缺的工具，特别是在血液学、癌症、传染病/免疫疾病、移植和再生医学等领域。克拉克亚特兰大大学（CAU）目前在MSM/AUC辐射安全办公室的监督下拥有一个伽玛赛尔辐照器。这是AUC联盟中唯一的伽马细胞辐照器，该联盟由四所历史悠久的黑人学院和大学（MSM， CAU，莫尔豪斯学院和斯佩尔曼学院）组成。在过去的18年里，自1994年CAU购买辐照器以来，包括NIH资助的MSM和CAU的研究人员在内的多名研究人员都受益于使用辐照器进行癌症、性传播传染病、中风和心血管疾病的再生医学研究，目的是消除健康差距。截至2010年12月31日，制造商发出了使用寿命周期终止信，不能再保证更换该设备的部件。因此，如果发生机械故障，而更换部件不在库存中，则辐照器将永久失效并必须退役。该仪器的持续可用性对于代表MSM四个部门的四个主要用户来说是必不可少的，他们正在进行NIH资助的健康差异研究。因此，我们正在申请资金，以购买一个新的伽玛赛尔辐照在MSM校园。MSM/AUC管理部门已同意为安装散热器的设施提供空间和财政支持，并签订预防性维护服务合同。MSM/AUC辐射安全计划将培训/协助用户，并监测设施的使用情况。该工具的可用性对于招募和培训有才能的学生和科学家至关重要，这些学生和科学家将成为明天的领导者，帮助解决服务不足的少数民族人口中存在的持续存在的健康差距。

DESCRIPTION (provided by applicant): We are requesting funds to purchase a gamma irradiator system (Gammacell 1000 Elite, Best Theratronics) to support NIH-funded basic health disparities-related research at Morehouse School of Medicine (MSM)/Atlanta University Center (AUC). The Gammacell 1000 Elite is a self-contained gamma irradiator using a cesium source. The irradiator is used for a variety of research purposes including, but not limited to: studying radiation-induced injury, sterilizing materials, selecting specific cell types, and suppressing immune reactions. It is, therefore, an indispensable instrument for biomedical research, in particular in the areas of hematology, cancer, infectious/immune diseases, transplantation, and regenerative medicine. Clark Atlanta University (CAU) currently houses one Gammacell irradiator under supervision of the MSM/AUC Radiation Safety Office. This is the only gamma cell Irradiator in the AUC Consortium, which consists of four Historically Black Colleges and Universities (MSM, CAU, Morehouse College, and Spelman College). For the past 18 years, since the irradiator was purchased by CAU in 1994, multiple investigators, including those supported by NIH grants at MSM and CAU have been benefiting from using the irradiator for their research in cancer, sexually transmittable infectious diseases, and regenerative medicine for stroke and cardiovascular disease with the purpose of eliminating health disparities. As of December 31, 2010, the manufacturer issued an end-of-useful-life- cycle letter and can no longer guarantee replacement parts on this unit. Consequently, if a mechanical malfunction occurs and replacement parts are not in inventory, the irradiator will become permanently disabled and subject to mandatory decommissioning. Continued availability of the instrument is indispensable to four major users representing four departments at MSM, who are conducting NIH- funded health disparities research. Thus, we are requesting funds to purchase a new Gammacell irradiator on MSM campus. MSM/AUC administration has agreed to commit space and financial support for a facility to house the irradiator as well as preventative maintenance service contracts. The MSM/AUC Radiation Safety Program will train/assist users and will monitor usage of the facility. The availability of the instrument is essential for recruiting and training talented students and scientists who will become tomorrow's leaders in helping to solve the persistent health disparities that exist in underserved minority populations.