Gammacell 1000 Elite Self-Contained Blood Irradiator

Gammacell 1000 Elite 独立式血液辐照器

• 批准号: 8442779
• 负责人: SHOBU NAMURA
• 金额: $ 29.92万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-25 至 2014-06-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8442779
• 关键词: Area; Biomedical Research; Blood; Cardiovascular Diseases; Cells; Cesium; Commit; Communicable Diseases; Contract Services; Disabled Persons; Equipment and supply inventories; Financial Support; Funding; Grant; Hematology; Historically Black Colleges and Universities; Housing; Immune; Immune System Diseases; Injury; Letters; Life Cycle Stages; Maintenance; Malignant Neoplasms; Manufacturer Name; Mechanics; Monitor; Morehouse School of Medicine; Population; Radiation; Reaction; Recruitment Activity; Regenerative Medicine; Research; Research Personnel; Safety; Scientist; Source; Stroke; Students; Supervision; System; Training; Transplantation; Underrepresented Minority; United States National Institutes of Health; Universities; cell type; college; health disparity; instrument; programs

DESCRIPTION (provided by applicant): We are requesting funds to purchase a gamma irradiator system (Gammacell 1000 Elite, Best Theratronics) to support NIH-funded basic health disparities-related research at Morehouse School of Medicine (MSM)/Atlanta University Center (AUC). The Gammacell 1000 Elite is a self-contained gamma irradiator using a cesium source. The irradiator is used for a variety of research purposes including, but not limited to: studying radiation-induced injury, sterilizing materials, selecting specific cell types, and suppressing immune reactions. It is, therefore, an indispensable instrument for biomedical research, in particular in the areas of hematology, cancer, infectious/immune diseases, transplantation, and regenerative medicine. Clark Atlanta University (CAU) currently houses one Gammacell irradiator under supervision of the MSM/AUC Radiation Safety Office. This is the only gamma cell Irradiator in the AUC Consortium, which consists of four Historically Black Colleges and Universities (MSM, CAU, Morehouse College, and Spelman College). For the past 18 years, since the irradiator was purchased by CAU in 1994, multiple investigators, including those supported by NIH grants at MSM and CAU have been benefiting from using the irradiator for their research in cancer, sexually transmittable infectious diseases, and regenerative medicine for stroke and cardiovascular disease with the purpose of eliminating health disparities. As of December 31, 2010, the manufacturer issued an end-of-useful-life- cycle letter and can no longer guarantee replacement parts on this unit. Consequently, if a mechanical malfunction occurs and replacement parts are not in inventory, the irradiator will become permanently disabled and subject to mandatory decommissioning. Continued availability of the instrument is indispensable to four major users representing four departments at MSM, who are conducting NIH- funded health disparities research. Thus, we are requesting funds to purchase a new Gammacell irradiator on MSM campus. MSM/AUC administration has agreed to commit space and financial support for a facility to house the irradiator as well as preventative maintenance service contracts. The MSM/AUC Radiation Safety Program will train/assist users and will monitor usage of the facility. The availability of the instrument is essential for recruiting and training talented students and scientists who will become tomorrow's leaders in helping to solve the persistent health disparities that exist in underserved minority populations.

描述（由申请人提供）：我们正在申请资金购买伽马辐照器系统（Gammacell 1000 Elite，Best Theratronics），以支持美国国立卫生研究院资助的Morehouse医学院（MSM）/亚特兰大大学中心（AUC）的基本卫生保健相关研究。Gammacell 1000 Elite是一种使用铯源的自给式伽马辐照器。辐照器用于各种研究目的，包括但不限于：研究辐射诱导的损伤，灭菌材料，选择特定的细胞类型和抑制免疫反应。因此，它是生物医学研究不可或缺的工具，特别是在血液学，癌症，传染性/免疫性疾病，移植和再生医学领域。克拉克亚特兰大大学（CAU）目前拥有一个Gammacell辐照器，由MSM/AUC辐射安全办公室监督。这是AUC联盟中唯一的伽马电池辐照器，该联盟由四所历史悠久的黑人学院和大学（MSM，CAU，Morehouse College和Spelman College）组成。在过去的18年里，自1994年CAU购买辐照器以来，多名研究人员，包括那些由NIH赠款的MSM和CAU的研究人员，一直受益于使用辐照器进行癌症，性传播感染性疾病以及中风和心血管疾病的再生医学研究，目的是消除健康差距。截至2010年12月31日，制造商发出了使用寿命周期终止函，不再保证该装置的更换部件。因此，如果发生机械故障，并且库存中没有更换部件，则辐照器将永久禁用并强制退役。该工具的持续可用性是不可或缺的四个主要用户代表四个部门在男男性接触者，谁正在进行美国国立卫生研究院资助的健康差距研究。因此，我们正在申请资金，以购买一个新的Gammacell辐照在MSM校园。MSM/AUC管理部门已同意为一个设施提供空间和财政支持，以容纳辐照器以及预防性维护服务合同。MSM/AUC辐射安全方案将培训/协助用户，并将监测设施的使用情况。该工具的可用性对于招募和培训有才华的学生和科学家至关重要，他们将成为明天的领导者，帮助解决服务不足的少数民族人口中存在的持续健康差距。