Rodent Holding for WIMR Cardiovascular Research

WIMR 心血管研究啮齿动物持有

• 批准号: 8524546
• 负责人: Richard L Moss
• 金额: $ 44.58万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8524546
• 关键词: Aging; Anesthesia procedures; Animal Experimentation; Animal Housing; Animals; Area; Arrhythmia; Beds; Behavioral Research; Biology; Biomedical Research; Cardiovascular system; Cells; Chemicals; Development; Elements; Embryo; Equipment; Faculty; Floor; Funding; Health; Heart failure; Housing; Institutes; Medical Research; Operative Surgical Procedures; Phase; Procedures; Public Health; Quarantine; Regenerative Medicine; Research; Research Personnel; Research Project Grants; Rodent; Safety; Schedule; Specific Pathogen Frees; Sterilization; United States National Institutes of Health; Universities; Wisconsin; Work; animal care; animal facility; cost; density; design; enzootic; germ free condition; improved; medical schools; operation; pathogen; programs; regenerative; square foot

DESCRIPTION (provided by applicant): The University of Wisconsin School of Medicine and Public Health (SMPH) recently completed the construction of a 29,960 gross square feet rodent facility in the Wisconsin Institutes for Medical Research (WIMR), and is nearing completion of a second research tower, WIMR Phase II, with occupancy scheduled for January 2014. Rodents currently housed elsewhere on campus will be moved into WIMR following successful embryo or cesarean rederivation. We seek to outfit three currently unequipped animal housing rooms (total 696 assignable square feet, ASF) with high-density caging and to properly equip the two adjacent procedure rooms (total 222 ASF). These rooms will provide animal housing for SMPH researchers affiliated with the Cardiovascular and Regenerative Medicine research floor of WIMR Phase II, which was supported by NIH ARRA C06 construction funding. These rooms will be utilized by 18 investigators and will have impact on research projects totaling more than $14 million in annual funding. The SMPH initially invested $12.6M for construction of the WIMR rodent vivarium including equipment for cage washing, sterilization, and bulk bedding dispensing. An additional $1.2M was allocated to purchase equipment for Suite 1 (of eight suites). Current university support includes an additional $3.9M to purchase equipment for Suites 2, 3, and 4 and a quarantine area, and $488,470 in SMPH matching funds to complete Suite 5 as outlined in this proposal. The proposed additions to the WIMR rodent vivarium Suite 5 include the purchase of high-density housing racks and cages, biosafety cabinets, a chemical fume hood, and an anesthesia station. These additions to the facility will provide researchers space within the footprint of the vivarium for animal housing and experimental procedures.

描述（由申请人提供）：威斯康星大学医学与公共卫生学院（SMPH）最近在威斯康星州医学研究机构（WIMR）建造了29,960个总面积的啮齿动物设施（WIMR），并正在建立第二阶段的第二阶段研究塔，并在2014年1月的count上进行了第二阶段的启动。剖宫产。我们寻求将三个目前未配备的动物住房室（总计696平方英尺，ASF）配备高密度笼子，并正确装备两个相邻的程序室（总计222个ASF）。这些房间将为WIMR II期的心血管和再生医学研究楼的SMPH研究人员提供动物住房，该研究人员得到了NIH ARRA C06建筑资金的支持。这些房间将由18名调查人员使用，并将对总计超过1400万美元的年资金产生影响。 SMPH最初投资了1,260万美元用于建造WIMR啮齿动物Vivarium，包括用于清洗，灭菌和散装床上用品的设备。额外的120万美元分配给了套房1（八个套房）的设备。目前的大学支持包括额外的390万美元购买套房2、3和4的设备以及隔离区，以及488,470美元的SMPH匹配资金，以完成该提案中概述的套房5。 WIMR啮齿动物Vivarium Suite 5的拟议补充包括购买高密度的外壳架和笼子，生物安全柜，化学通风罩和麻醉站。这些对设施的补充将为研究人员提供动物住房和实验程序的占地面积。