Rodent Holding for WIMR Cardiovascular Research

描述(由申请人提供)：威斯康星大学医学与公共卫生学院(SMPH)最近完成了在威斯康星医学研究所(WIMR)建造一个29960平方英尺的啮齿动物设施，并即将完成第二座研究塔楼，WIMR二期，计划于2014年1月入驻。目前寄养在校园其他地方的啮齿动物将在成功胚胎或剖腹产后被转移到WIMR。我们寻求为三个目前未配备设备的动物房(总计696平方英尺，ASF)配备高密度笼子，并为相邻的两个程序室(总计222个ASF)配备适当的设备。这些房间将为附属于WIMR第二阶段心血管和再生医学研究楼层的SMPH研究人员提供动物住房，该项目得到了NIH ARRA C06建设资金的支持。这些房间将由18名调查人员使用，并将对每年总计超过1400万美元的研究项目产生影响。SMPH最初投资1260万美元建造WIMR啮齿动物隔间，包括笼子清洗、消毒和散装床上用品分配的设备。另外拨出120万美元，用于购买套间1(共8套)的设备。目前的大学支持包括额外的390万美元，用于购买Suite 2、Suite 3和Suite 4以及隔离区的设备，以及488,470美元的SMPH匹配资金，以完成本提案中概述的Suite 5。WIMR Varium Suite 5的拟议新增内容包括购买高密度住房机架和笼子、生物安全柜、化学通风柜和麻醉站。这些设施的增加将为研究人员提供隔膜足迹内的空间，用于动物收容和实验程序。

DESCRIPTION (provided by applicant): The University of Wisconsin School of Medicine and Public Health (SMPH) recently completed the construction of a 29,960 gross square feet rodent facility in the Wisconsin Institutes for Medical Research (WIMR), and is nearing completion of a second research tower, WIMR Phase II, with occupancy scheduled for January 2014. Rodents currently housed elsewhere on campus will be moved into WIMR following successful embryo or cesarean rederivation. We seek to outfit three currently unequipped animal housing rooms (total 696 assignable square feet, ASF) with high-density caging and to properly equip the two adjacent procedure rooms (total 222 ASF). These rooms will provide animal housing for SMPH researchers affiliated with the Cardiovascular and Regenerative Medicine research floor of WIMR Phase II, which was supported by NIH ARRA C06 construction funding. These rooms will be utilized by 18 investigators and will have impact on research projects totaling more than $14 million in annual funding. The SMPH initially invested $12.6M for construction of the WIMR rodent vivarium including equipment for cage washing, sterilization, and bulk bedding dispensing. An additional $1.2M was allocated to purchase equipment for Suite 1 (of eight suites). Current university support includes an additional $3.9M to purchase equipment for Suites 2, 3, and 4 and a quarantine area, and $488,470 in SMPH matching funds to complete Suite 5 as outlined in this proposal. The proposed additions to the WIMR rodent vivarium Suite 5 include the purchase of high-density housing racks and cages, biosafety cabinets, a chemical fume hood, and an anesthesia station. These additions to the facility will provide researchers space within the footprint of the vivarium for animal housing and experimental procedures.