Rodent Holding for WIMR Cardiovascular Research

WIMR 心血管研究啮齿动物持有

• 批准号: 8524546
• 负责人: Richard L Moss
• 金额: $ 44.58万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8524546
• 关键词: Aging; Anesthesia procedures; Animal Experimentation; Animal Housing; Animals; Area; Arrhythmia; Beds; Behavioral Research; Biology; Biomedical Research; Cardiovascular system; Cells; Chemicals; Development; Elements; Embryo; Equipment; Faculty; Floor; Funding; Health; Heart failure; Housing; Institutes; Medical Research; Operative Surgical Procedures; Phase; Procedures; Public Health; Quarantine; Regenerative Medicine; Research; Research Personnel; Research Project Grants; Rodent; Safety; Schedule; Specific Pathogen Frees; Sterilization; United States National Institutes of Health; Universities; Wisconsin; Work; animal care; animal facility; cost; density; design; enzootic; germ free condition; improved; medical schools; operation; pathogen; programs; regenerative; square foot

DESCRIPTION (provided by applicant): The University of Wisconsin School of Medicine and Public Health (SMPH) recently completed the construction of a 29,960 gross square feet rodent facility in the Wisconsin Institutes for Medical Research (WIMR), and is nearing completion of a second research tower, WIMR Phase II, with occupancy scheduled for January 2014. Rodents currently housed elsewhere on campus will be moved into WIMR following successful embryo or cesarean rederivation. We seek to outfit three currently unequipped animal housing rooms (total 696 assignable square feet, ASF) with high-density caging and to properly equip the two adjacent procedure rooms (total 222 ASF). These rooms will provide animal housing for SMPH researchers affiliated with the Cardiovascular and Regenerative Medicine research floor of WIMR Phase II, which was supported by NIH ARRA C06 construction funding. These rooms will be utilized by 18 investigators and will have impact on research projects totaling more than $14 million in annual funding. The SMPH initially invested $12.6M for construction of the WIMR rodent vivarium including equipment for cage washing, sterilization, and bulk bedding dispensing. An additional $1.2M was allocated to purchase equipment for Suite 1 (of eight suites). Current university support includes an additional $3.9M to purchase equipment for Suites 2, 3, and 4 and a quarantine area, and $488,470 in SMPH matching funds to complete Suite 5 as outlined in this proposal. The proposed additions to the WIMR rodent vivarium Suite 5 include the purchase of high-density housing racks and cages, biosafety cabinets, a chemical fume hood, and an anesthesia station. These additions to the facility will provide researchers space within the footprint of the vivarium for animal housing and experimental procedures.

描述（由申请人提供）：威斯康星州大学医学与公共卫生学院（SMPH）最近完成了威斯康星州医学研究所（WIMR）29，960总平方英尺啮齿动物设施的建设，并即将完成第二个研究塔，WIMR第二阶段，预计于2014年1月入住。目前居住在校园其他地方的啮齿动物将在胚胎成功或剖腹产后被转移到WIMR。我们寻求为三个目前未配备设备的动物饲养室（总计696可分配平方英尺，ASF）配备高密度笼舍，并适当配备两个相邻的手术室（总计222 ASF）。这些房间将为隶属于WIMR第二阶段心血管和再生医学研究楼层的SMPH研究人员提供动物住房，该研究由NIH ARRA C06建设资金支持。这些房间将由18名研究人员使用，并将对研究项目产生影响，每年的资金总额超过1400万美元。SMPH最初投资1260万美元用于建设WIMR啮齿动物饲养场，包括笼清洗、消毒和散装垫料分配设备。另外分配了120万美元用于购买1号套房（共8间套房）的设备。目前的大学支持包括额外的390万美元，用于购买套房2，3和4和隔离区的设备，以及488，470美元的SMPH配套资金，以完成本提案中概述的套房5。WIMR啮齿动物饲养室5号套房的拟议增加包括购买高密度饲养架和笼子、生物安全柜、化学通风柜和麻醉站。这些设施的增加将为研究人员提供动物饲养场和实验程序的空间。