Rodent Holding for WIMR Cardiovascular Research

WIMR 心血管研究啮齿动物持有

• 批准号: 8524546
• 负责人: Richard L Moss
• 金额: $ 44.58万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8524546
• 关键词: Aging; Anesthesia procedures; Animal Experimentation; Animal Housing; Animals; Area; Arrhythmia; Beds; Behavioral Research; Biology; Biomedical Research; Cardiovascular system; Cells; Chemicals; Development; Elements; Embryo; Equipment; Faculty; Floor; Funding; Health; Heart failure; Housing; Institutes; Medical Research; Operative Surgical Procedures; Phase; Procedures; Public Health; Quarantine; Regenerative Medicine; Research; Research Personnel; Research Project Grants; Rodent; Safety; Schedule; Specific Pathogen Frees; Sterilization; United States National Institutes of Health; Universities; Wisconsin; Work; animal care; animal facility; cost; density; design; enzootic; germ free condition; improved; medical schools; operation; pathogen; programs; regenerative; square foot

DESCRIPTION (provided by applicant): The University of Wisconsin School of Medicine and Public Health (SMPH) recently completed the construction of a 29,960 gross square feet rodent facility in the Wisconsin Institutes for Medical Research (WIMR), and is nearing completion of a second research tower, WIMR Phase II, with occupancy scheduled for January 2014. Rodents currently housed elsewhere on campus will be moved into WIMR following successful embryo or cesarean rederivation. We seek to outfit three currently unequipped animal housing rooms (total 696 assignable square feet, ASF) with high-density caging and to properly equip the two adjacent procedure rooms (total 222 ASF). These rooms will provide animal housing for SMPH researchers affiliated with the Cardiovascular and Regenerative Medicine research floor of WIMR Phase II, which was supported by NIH ARRA C06 construction funding. These rooms will be utilized by 18 investigators and will have impact on research projects totaling more than $14 million in annual funding. The SMPH initially invested $12.6M for construction of the WIMR rodent vivarium including equipment for cage washing, sterilization, and bulk bedding dispensing. An additional $1.2M was allocated to purchase equipment for Suite 1 (of eight suites). Current university support includes an additional $3.9M to purchase equipment for Suites 2, 3, and 4 and a quarantine area, and $488,470 in SMPH matching funds to complete Suite 5 as outlined in this proposal. The proposed additions to the WIMR rodent vivarium Suite 5 include the purchase of high-density housing racks and cages, biosafety cabinets, a chemical fume hood, and an anesthesia station. These additions to the facility will provide researchers space within the footprint of the vivarium for animal housing and experimental procedures.

描述（由申请人提供）：威斯康星大学医学与公共卫生学院 (SMPH) 最近在威斯康星医学研究所 (WIMR) 完成了总面积 29,960 平方英尺的啮齿动物设施的建设，第二座研究塔 WIMR 二期工程即将竣工，计划于 2014 年 1 月入住。目前安置在校园其他地方的啮齿动物将在成功胚胎或胚胎移植后转移到 WIMR。 剖宫产重新衍生。我们寻求为三个目前未配备的动物饲养室（总共 696 可分配平方英尺，ASF）配备高密度笼子，并正确装备两个相邻的手术室（总共 222 ASF）。这些房间将为隶属于 WIMR 二期心血管和再生医学研究楼层的 SMPH 研究人员提供动物住房，该研究得到 NIH ARRA C06 建设资金的支持。这些房间将由 18 名研究人员使用，将对每年资助总额超过 1400 万美元的研究项目产生影响。 SMPH 最初投资 1,260 万美元用于建设 WIMR 啮齿动物饲养场，包括笼子清洗、消毒和散装垫料分配设备。额外拨款 120 万美元用于购买套件 1（共八个套件）的设备。目前的大学支持包括额外 390 万美元购买 2、3 和 4 号套房和隔离区的设备，以及 SMPH 的 488,470 美元配套资金以完成本提案中概述的 5 号套房。 WIMR 啮齿动物饲养室 Suite 5 的拟议新增设施包括购买高密度饲养架和笼子、生物安全柜、化学通风柜和麻醉站。该设施的这些新增设施将为研究人员在动物园的占地面积内提供用于动物饲养和实验程序的空间。