Rodent Holding for WIMR Cardiovascular Research

描述（由申请人提供）：威斯康星大学医学和公共卫生学院（SMPH）最近在威斯康星医学研究所（WIMR）完成了一个29,960总平方英尺的啮齿动物设施的建设，并且即将完成第二个研究塔，WIMR二期，计划于2014年1月入住。目前被安置在校园其他地方的啮齿动物将在胚胎或剖宫产再生成功后转移到WIMR。我们试图为三个目前没有设备的动物饲养室（总共696平方英尺，ASF）配备高密度的笼子，并为相邻的两个手术室（总共222平方英尺）配备适当的设备。这些房间将为隶属于WIMR二期心血管和再生医学研究楼层的SMPH研究人员提供动物住房，该研究由NIH ARRA C06建设资金支持。这些房间将供18名研究人员使用，并将对年度资金总额超过1400万美元的研究项目产生影响。SMPH最初投资1260万美元建造WIMR啮齿动物饲养箱，包括笼子清洗、消毒和散装床上用品分发设备。另外拨出120万美元用于购买1号套房（共8个套房）的设备。目前的大学支持包括额外的390万美元，用于购买套房2、3、4和隔离区的设备，以及488,470美元的SMPH配套资金，用于完成本提案中概述的套房5。建议增加的WIMR啮齿动物实验室套房5包括购买高密度住房机架和笼子、生物安全柜、化学通风柜和麻醉站。这些设施的增加将为研究人员提供动物饲养和实验程序的空间。

DESCRIPTION (provided by applicant): The University of Wisconsin School of Medicine and Public Health (SMPH) recently completed the construction of a 29,960 gross square feet rodent facility in the Wisconsin Institutes for Medical Research (WIMR), and is nearing completion of a second research tower, WIMR Phase II, with occupancy scheduled for January 2014. Rodents currently housed elsewhere on campus will be moved into WIMR following successful embryo or cesarean rederivation. We seek to outfit three currently unequipped animal housing rooms (total 696 assignable square feet, ASF) with high-density caging and to properly equip the two adjacent procedure rooms (total 222 ASF). These rooms will provide animal housing for SMPH researchers affiliated with the Cardiovascular and Regenerative Medicine research floor of WIMR Phase II, which was supported by NIH ARRA C06 construction funding. These rooms will be utilized by 18 investigators and will have impact on research projects totaling more than $14 million in annual funding. The SMPH initially invested $12.6M for construction of the WIMR rodent vivarium including equipment for cage washing, sterilization, and bulk bedding dispensing. An additional $1.2M was allocated to purchase equipment for Suite 1 (of eight suites). Current university support includes an additional $3.9M to purchase equipment for Suites 2, 3, and 4 and a quarantine area, and $488,470 in SMPH matching funds to complete Suite 5 as outlined in this proposal. The proposed additions to the WIMR rodent vivarium Suite 5 include the purchase of high-density housing racks and cages, biosafety cabinets, a chemical fume hood, and an anesthesia station. These additions to the facility will provide researchers space within the footprint of the vivarium for animal housing and experimental procedures.