Priming the Pump: Training Physician-Scientists for Translational Neuroscience

6.项目摘要 这项建议旨在开发和实施住院医师培训研究轨道，明确目标是招聘在开展研究方面有记录的医学博士和医学毕业生。该计划将提供对临床研究的早期接触，以激发我们的基础科学实习生对翻译研究的兴趣。该计划在住院和门诊临床研究环境中提供7个月的转化性研究机会，并为指导研究项目提供16个月的保护性时间。在这几个月里，将通过由私人投资机构监督的密集指导以及专注于伦理学、统计学、研究设计和翻译研究原则的指导来加强这几个月的“元指导”。所有这些都将在满足ACGME要求的同时实现，从而使毕业生具有董事会资格。我们预计，这样的轨道，我们概念为4年的计划，将允许研究轨道居民“启动”他们的研究生涯，同时仍然是居民，使他们更好地为研究奖学金和K奖励过程做准备，最终导致职业生涯的独立调查人员。由于这是一个通向董事会资格的为期4年的项目，我们为受训人员提供了一条“无风险”的道路，以提高作为独立调查人员成功的可能性。这种方法旨在补救目前的状况，在这种情况下，医学博士和博士在由于临床培训的需要而造成的中断后，经常面临重新开始他们的研究。我们预计将教育内科科学家，以加强翻译研究人员的管道，这是NIMH的一个关键目标。

6. Project Abstract This proposal aims to develop and implement a residency training research track with the explicit goal of recruiting MD, PhD and medical graduates with a track record in conducting research. The program will provide early exposure to clinical research to stimulate interest in translational research among our basic science trainees. The program provides 7 months of exposure to translational research in both inpatient and outpatient clinical research settings, and 16 months of protected time for a mentored research project. These months will be augmented by intensive mentoring, overseen by the Pis, functioning as "meta-mentors," as well as preceptorship focused on ethics, statistics, research design and principles of translational research. All this will be attained while meeting ACGME requirements so that graduates will be board eligible. We anticipate that such a track, which we conceptualize as a 4 year program, will permit research track residents to "jump start" their research career while still residents, rendering them better prepared for research fellowships and the K award process, ultimately leading to careers as independent investigators. Because this is a 4 year program leading to board eligibility, we offer our trainees a "no-risk" path towards enhanced likelihood of success as independent investigators. This approach is intended to remedy the current state of affairs wherein MD, PhDs often are faced with "re-starting" their research after a hiatus created by the need for clinical training. We anticipate educating physician-scientists to enhance the pipeline of translational investigators, a key goal of the NIMH.