Mouse Immunopathology

申请人寻求职业生涯中期研究人员的支持，以进行密集的小鼠免疫病理学研究 利用比较病理学方法进行研究并指导小鼠病理生物学的初级研究人员 研究。陈柳医生是一名获得委员会认证的外科病理学家。他是副教授、麻省理工学院院长 胃肠和肝脏病理服务，以及胃肠/肝脏病理研究员培训主任 程序。刘博士积极参与临床患者护理、基础和翻译研究。 模型和指导临床研究员、住院医生、博士后研究员、研究生和 本科生。刘博士的主要研究重点是丙型肝炎病毒感染的免疫病理学， 目前由美国国立卫生研究院拨款支持。他的团队已经建立了新的老鼠模型来研究 病毒感染中的免疫反应。在这项提议中，他将研究T细胞反应和 丙型肝炎病毒感染中的调节性T细胞。他将测试新的策略，以利用免疫反应来对抗 丙型肝炎病毒感染。刘博士的研究小组由非常有才华的年轻博士后研究员组成， 研究生、住院医生/跟随者、医学生和本科生。我们的目标是指导 开始研究成为未来的研究人员，他们在老鼠和人类方面都有专长 免疫病理学。此外，刘博士还在MICE方面建立了国际合作 免疫病理学研究。通过这些研究，刘博士确立了自己在 比较小鼠免疫病理学。在过去的8年里，刘博士与人合著了63篇同行评议 文章和9本书的章节/评论。在研究所内，刘博士是一位久负盛名的病理学家 在人类和老鼠系统方面的专业知识。他参与了有关自身免疫性疾病的研究项目 使用鼠标模型。由于这些广泛的正在进行的研究活动，刘博士打算 专门培训新的研究人员，以满足生物医学领域对小鼠病理学家日益增长的需求 研究。佛罗里达大学拥有169,026平方英尺的综合动物护理设施 空间容纳了350多个品系的小鼠和1400个经批准的研究方案。使用附加的 通过在当地和全国范围内的合作，该机构将为刘博士的 职业发展和指导下一代老鼠病理生物学家。K26职业生涯中期奖是 支持刘博士实现这一目标的良好机制。 相关性(请参阅说明)：‘ 丙型肝炎病毒是一种没有预防性疫苗的人类主要传染病。这项研究将调查 利用小鼠模型进行免疫反应，这将有助于开发新的疫苗。通过这项研究， 研究人员将指导年轻的研究人员进行老鼠病理生物学研究。

The applicant seeks support for a midcareer investigator to conduct intensive mouse immunopathology research using comparative pathology approach and to mentor beginning investigators in mouse pathbiology research. Dr. Chen Liu is a board-certified surgical pathologist. He is an Associate Professor, the Director of Gastrointestinal and Liver Pathology Service, and the Director of GI/Liver Pathology Fellowship training program. Dr .Liu is actively engaged in clinical patient care, basic and translational research using moue models, and mentoring clinical fellows, residents, postdoctoral fellows, graduate students, and undergraduate students. Dr. Liu's primary research focus is immunopathology of hepatitis C viral infection, which is currently supported by NIH grants. His team has established novel mouse models to investigate immune responses in viral infection. In this proposal, he will study the T cell response and the function of regulatory T cells in HCV infection. He will test novel strategies to harness the immune response against HCV infection. Dr. Liu's research group consists of very talented young postdoctoral research fellows, graduate students, residents/follows, medical student, and undergraduate student. The goal is to mentor beginning investigators to become future investigators who have the expertise in both mouse and human immunopathology. In addition, Dr. Liu has established international collaborations on mouse immuopathology research. Through these studies, Dr. Liu has established himself as an expert in comparative mouse immunopathology. Over the past 8 years, Dr. Liu has co-authored 63 peer-reviewed articles and 9 book chapters/reviews. Within the Institution, Dr. Liu is a well-established pathologist who has expertise in both human and mouse systems. He is involved in research projects on autoimmune diseases using mouse models. Because of these extensive ongoing research activities, Dr. Liu intends to have dedicated time to train new investigators who will fill the growing need of mouse pathologist in biomedical research. The University of Florida has a comprehensive animal care facility with 169,026 square feet of space that hosts more than 350 strains of mice and 1,400 approved research protocols. With additional collaborations locally and nationally, the institution will provide an outstanding environment for Dr. Liu's career development and mentoring next generation of mouse pathobiologists. The K26 midcareer award is an excellent mechanism to support Dr. Liu to achieve this goal. RELEVANCE (See instructions): ' Hepatitis C virus is a major human infectious disease without preventive vaccine. This study will investigate the immune responses using a mouse model, which will help develop novel vaccines. Through this study, the investigator will mentor young investigators for mouse pathobioplogy study.