Building on the success of the adoptive immunotherapy of cancer

癌症的过继免疫治疗：在成功的基础上，我们在理解T细胞介导的抗肿瘤反应的分子和细胞基础方面取得了实质性进展。T细胞是适应性抗肿瘤免疫反应的有效效应者。肿瘤反应性CD8T细胞识别的一些靶抗原是肿瘤细胞也表达的非突变自身抗原。调节T细胞激活、功能和记忆的分子信号正在被阐明。来自共刺激分子的积极和消极信号都已被证明塑造了抗肿瘤反应。细胞因子，包括那些含有共同的细胞因子受体伽马链的受体，已经被证明改变了效应器CD8T细胞的编程。

Adoptive immunotherapy for cancer: building on success Substantial progress has been made in our understanding of the molecular and cellular bases of T cell mediated anti-tumor responses. T cells are potent effectors of the adaptive anti-tumor immune response. Some target antigens recognized by tumor-reactive CD8+ T cells are non-mutated self-antigens that are also expressed by tumor cells. The molecular signals that modulate T cell activation, function and memory are being elucidated. Both positive and negative signals from co-stimulatory molecules have been shown to shape the anti-tumor response. Cytokines, including those with receptors that contain the common cytokine-receptor gamma chain have been shown to alter the programming of effector CD8+ T cells.