Case GI SPORE
案例 GI 孢子
基本信息
- 批准号:8528379
- 负责人:
- 金额:$ 215.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-14 至 2016-08-31
- 项目状态:已结题
- 来源:
- 关键词:Aberrant DNA MethylationAccountingAdenocarcinomaAdultAllelesAmericanArchivesAttentionBarrett EsophagusBarrett&aposs AdenocarcinomaBasic ScienceBiologicalBiological MarkersCancer CenterCancer EtiologyCancer Gene MutationCessation of lifeChemopreventionClinicalClinical InvestigatorColon CarcinomaColonic AdenomaColonic NeoplasmsColorectal CancerComprehensive Cancer CenterDNADetectionDevelopmentDiseaseDisseminated Malignant NeoplasmEarly DiagnosisEarly treatmentEnsureEsophageal AdenocarcinomaEsophagusEthnic OriginEvaluationExperimental PathologyFacultyFamilyFecesFormalinFosteringGenderGene MutationGenesGeneticGenetic ProgrammingGenetic ScreeningGenomeGenomicsIncidenceIndividualJointsLesionMalignant NeoplasmsMalignant neoplasm of esophagusMalignant neoplasm of gastrointestinal tractMethodsModalityMolecularMolecular ProfilingMorbidity - disease rateMutationNew AgentsNonmetastaticOutcomePathway interactionsPatientsPersonsPlayPremalignantPreventionProcessRecurrenceResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesRisk AssessmentRisk ReductionSampling StudiesSeriesServicesSpecialized Program of Research ExcellenceStagingStatistical MethodsSurvival RateSusceptibility GeneTechnologyTestingTherapeuticTissue SampleTranslational ResearchUnited Statesbasecancer chemopreventioncancer geneticscancer genomecancer therapycareer developmentdisorder controldrug discoverygastrointestinalhigh throughput screeningkindredmortalitynamed groupneoplasticnext generationnext generation sequencingnovelnovel strategiesoutcome forecastprognosticprogramsresearch and developmentresponsescreeningtumor
项目摘要
This Case Gl SPORE proposal provides for a cutting edge Specialized Program of Research Excellence in gastrointestinal malignancies with emphasis on colorectal cancers and with additional attention to adenocarcinoma of the esophagus. This comprehensive program builds on the resources of the Case Comprehensive Cancer Center to propose 4 translational Research Projects to bring new molecular advances to patients with Gl Cancers. A series of 4 core resources support these research projects and also establish a strong programmatic infrastructure for translational research in Gl cancers. We further have developed a comprehensive infrastructure for identifying new Developmental Research Projects from basic science and clinical investigators from across the Case Cancer Center. Moreover, drawing on our strong track record of developing new faculty who emphasize translational research in Gl cancers, we propose a targeted Career Development Program to further enhance the translational research cadre of SPORE faculty. The 4 SPORE translational research projects constitute novel and cutting edge approaches to Gl cancers and include studies of: the predictive, prognostic, and therapeutic applications of the new 15-PGDH colon cancer suppressor pathway (Project 1, Drs. Markowitz and Willson); the noninvasive early detection of advanced colon adenomas through stool DNA testing for methylated DNA (Project 2, Drs. Cooper and Li); the comprehensive evaluation of colon cancer gene mutations as predictors of clinical outcome, via use of high throughput Next Generation genomic sequencing (Project 3, Drs. Willis and Wang); and the identification of esophageal adenocarcinoma susceptibility genes (Project 4, Drs. Chak and Elston). These projects are advantaged by special population and scientific resources developed by our SPORE faculty for: evaluation of colon cancer biomarkers, for high throughput screening for new drug discovery, for evaluation of colon cancer screening modalities, for Next Generation sequencing from archived formalin fixed tissue samples, and for study of familial Barrett's and adenocarcinomas of the esophagus. The strength of these investigators and the resources at their disposal will ensure this program leads to important advances.
该案例Gl SPORE提案提供了胃肠道恶性肿瘤研究卓越的尖端专业计划,重点是结直肠癌,并额外关注食管腺癌。这个综合性的计划建立在病例综合癌症中心的资源基础上,提出了4个转化研究项目,为GI癌症患者带来新的分子进展。一系列4个核心资源支持这些研究项目,并为GI癌症的转化研究建立了强大的程序基础设施。我们还开发了一个全面的基础设施,用于从整个病例癌症中心的基础科学和临床研究人员中确定新的发展研究项目。此外,借鉴我们在发展强调GI癌症转化研究的新教师方面的良好记录,我们提出了一个有针对性的职业发展计划,以进一步加强SPORE教师的转化研究骨干。4个SPORE转化研究项目构成了GI癌症的新的和前沿的方法,包括以下研究:新的15-PGDH结肠癌抑制途径的预测,预后和治疗应用(项目1,Markowitz和Willson博士);通过粪便DNA检测甲基化DNA的非侵入性早期检测晚期结肠腺瘤(项目2,库珀和Li博士);通过使用高通量下一代基因组测序对结肠癌基因突变作为临床结果预测因子的综合评价(项目3,Willis和Wang博士);以及食管腺癌易感基因的鉴定(项目4,Chak和Elston博士)。这些项目由我们的SPORE教师开发的特殊人群和科学资源支持:结肠癌生物标志物的评估,新药发现的高通量筛选,结肠癌筛选模式的评估,从存档的福尔马林固定组织样本中进行下一代测序,以及家族性巴雷特和食管腺癌的研究。这些研究人员的力量和他们所掌握的资源将确保该计划取得重要进展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SANFORD D. MARKOWITZ其他文献
SANFORD D. MARKOWITZ的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SANFORD D. MARKOWITZ', 18)}}的其他基金
Chemical, Structural and Cell-Signaling Interrogation of 15-Prostanglandin Dehydrogenase in Tissue Repair and Regeneration
15-前列腺素脱氢酶在组织修复和再生中的化学、结构和细胞信号传导研究
- 批准号:
10627860 - 财政年份:2021
- 资助金额:
$ 215.05万 - 项目类别:
Targeting 15-Prostaglandin Dehydrogenase (15-PGDH) in Cancer Risk, Prevention, and Treatment
针对癌症风险、预防和治疗中的 15-前列腺素脱氢酶 (15-PGDH)
- 批准号:
9406781 - 财政年份:2016
- 资助金额:
$ 215.05万 - 项目类别:
Targeting 15-Prostaglandin Dehydrogenase (15-PGDH) in Cancer Risk, Prevention, and Treatment
针对癌症风险、预防和治疗中的 15-前列腺素脱氢酶 (15-PGDH)
- 批准号:
10524057 - 财政年份:2016
- 资助金额:
$ 215.05万 - 项目类别:
Targeting 15-Prostaglandin Dehydrogenase (15-PGDH) in Cancer Risk, Prevention, and Treatment
针对癌症风险、预防和治疗中的 15-前列腺素脱氢酶 (15-PGDH)
- 批准号:
10305660 - 财政年份:2016
- 资助金额:
$ 215.05万 - 项目类别:
Targeting 15-Prostaglandin Dehydrogenase (15-PGDH) in Cancer Risk, Prevention, and Treatment
针对癌症风险、预防和治疗中的 15-前列腺素脱氢酶 (15-PGDH)
- 批准号:
9183207 - 财政年份:2016
- 资助金额:
$ 215.05万 - 项目类别:
Targeting 15-Prostaglandin Dehydrogenase (15-PGDH) in Cancer Risk, Prevention, and Treatment
针对癌症风险、预防和治疗中的 15-前列腺素脱氢酶 (15-PGDH)
- 批准号:
10058813 - 财政年份:2016
- 资助金额:
$ 215.05万 - 项目类别:
Role of gene enhancer elements in colon cancer
基因增强子元件在结肠癌中的作用
- 批准号:
8449075 - 财政年份:2012
- 资助金额:
$ 215.05万 - 项目类别:
Role of gene enhancer elements in colon cancer
基因增强子元件在结肠癌中的作用
- 批准号:
8289140 - 财政年份:2012
- 资助金额:
$ 215.05万 - 项目类别:
Role of gene enhancer elements in colon cancer
基因增强子元件在结肠癌中的作用
- 批准号:
8633432 - 财政年份:2012
- 资助金额:
$ 215.05万 - 项目类别:
Targeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and Prevention
以 15-PGDH 为靶点进行结肠癌的预后、预测、治疗和预防
- 批准号:
8555227 - 财政年份:2011
- 资助金额:
$ 215.05万 - 项目类别:
相似海外基金
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 215.05万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
- 批准号:
10100360 - 财政年份:2024
- 资助金额:
$ 215.05万 - 项目类别:
Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
- 批准号:
24K04974 - 财政年份:2024
- 资助金额:
$ 215.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
- 批准号:
2312319 - 财政年份:2023
- 资助金额:
$ 215.05万 - 项目类别:
Standard Grant
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
- 批准号:
23K01686 - 财政年份:2023
- 资助金额:
$ 215.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
- 批准号:
23K01692 - 财政年份:2023
- 资助金额:
$ 215.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
- 批准号:
23K01695 - 财政年份:2023
- 资助金额:
$ 215.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
- 批准号:
23K01713 - 财政年份:2023
- 资助金额:
$ 215.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
- 批准号:
23K01715 - 财政年份:2023
- 资助金额:
$ 215.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
- 批准号:
10585388 - 财政年份:2023
- 资助金额:
$ 215.05万 - 项目类别: