Clinical Oncology Program Biostatistical Center

临床肿瘤学项目生物统计中心

• 批准号: 8520189
• 负责人: JOSEPH P. COSTANTINO
• 金额: $ 369.86万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8520189
• 关键词: Accounting; American Cancer Society; Ancillary Study; Breast Cancer Prevention Trial; Cancer Control; Cessation of life; Clinical Oncology; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Design; Collaborations; Collection; Colorectal Cancer; Communication; Community Clinical Oncology Program; Community Physician; Controlled Clinical Trials; Correlative Study; Data; Data Collection; Data Quality; Development; Disease; Enrollment; Ensure; Fostering; Funding; Funding Opportunities; Goals; Incidence; Institution; Instruction; Leadership; Malignant Neoplasms; Methodology; Minority; Monitor; National Surgical Adjuvant Breast and Bowel Project; Participant; Patients; Performance; Persons; Prevention; Procedures; Public Health; Publishing; Quality of life; Randomized Clinical Trials; Reporting; Research; Research Design; Research Personnel; Research Proposals; Services; Training; Tumor Biology; Woman; base; cancer prevention; cancer therapy; clinical research site; colorectal cancer prevention; computerized data processing; data integrity; data management; design; improved; malignant breast neoplasm; member; new technology; oncology program; operation; programs; quality assurance; standard of care; statistical center; treatment trial

DESCRIPTION (provided by applicant): The American Cancer Society estimates that annually there are more than 350,000 new cases of breast or colorectal cancers and almost 100,000 deaths related to these cancers. This is a substantial public health problem that remains the focus the National Surgical Adjuvant Breast and Bowel Project (NSABP). For more than 50 years, the NSABP has successfully conducted large-scale, randomized clinical trials in breast and colorectal cancer designed to improve the standard of care, quality of life and survival of persons who develop these diseases. Since 1984, when NSABP became a CCOP Research Base, the CCOP investigators have accounted for approximately 30,000 treatment trial patients and more than 33,100 participants have been enrolled in the BCPT and STAR breast cancer prevention trials. The timeliness and quality of data obtained through these programs have been exceptional and have contributed positively to overall NSABP data integrity and have substantially enhanced the base of scientific information regarding the treatment and prevention of cancer. In the proposed project period, funding will be used to sustain our efforts as a data and statistical center in support of the NSABP CCOP treatment, cancer control and prevention scientific agenda. In that capacity, we will continue to enhance the utilization of newer technologies for data collection, data management and the communication and training of clinical site collaborators with the goal of developing more efficient methodologies to design, conduct and analyze clinical trials, This research proposal requests funding to enable the continued functioning of the CCOP, MB-CCOP and Prevention components of the NSABP Biostatistical Center which provide: 1) data management support for the collection and processing of data from NSABP trials; 2) quality assurance programs which ensure that the collected data is of the highest integrity; 3) scientific collaboration in the development of the NSABP research agenda and logistical support for the conduct of the research; and 4) statistical leadership and support for the design, monitoring and analysis of trials and correlative studies. RELEVANCE (See instructions): Breast and Colorectal cancer is a substantial public health problem that is the focus of the National Surgical Adjuvant Breast and Bowel Project (NSABP). The focus of the NSABP is the conduct of large-scale, clinical trials designed to improve the standard of care, quality of life and survival of persons who develop these diseases as well as the conduct of breast and colorectal cancer prevention studies. Our current and planned studies are designed to improve the prevention and treatment of these diseases.

描述（由申请人提供）：美国癌症协会估计，每年有350,000例乳腺癌或结直肠癌的新病例，与这些癌症有关的近100,000例死亡。这是一个实质性的公共卫生问题，仍然是国家手术辅助乳房和肠项目（NSABP）的重点。 50多年来，NSABP在乳腺癌和结直肠癌方面成功进行了大规模的随机临床试验，旨在提高发展这些疾病的人的护理，生活质量和生存标准。自1984年，NSABP成为CCOP研究基础以来，CCOP研究人员已占30,000名治疗试验患者，并且已招募了33,100名参与者参加了BCPT和Star乳腺癌预防试验。通过这些程序获得的数据的及时性和质量非常出色，并为NSABP数据完整性做出了积极贡献，并显着增强了有关癌症治疗和预防的科学信息的基础。在拟议的项目期间，资金将用于维持我们作为数据和统计中心的努力，以支持NSABP CCOP治疗，癌症控制和预防科学议程。以这种能力，我们将继续增强对数据收集，数据管理以及临床站点合作者的沟通和培训的新技术的利用，目的是开发更有效的方法来设计，进行和分析临床试验，该研究建议要求资金促进CCOP，MB-CCCOP和MB-CCOP和PREVITION COMPLITITY COMPLITITY COMPLITITY COMPLITITING的资金： NSABP试验的数据； 2）质量保证计划，以确保收集的数据具有最高的完整性； 3）在NSABP研究议程的发展方面的科学合作和对研究进行的后勤支持； 4）对试验和相关研究的设计，监视和分析的统计领导和支持。 相关性（请参阅说明）：乳腺癌和大肠癌是一个实质性的公共卫生问题，是国家手术辅助乳房和肠项目（NSABP）的重点。 NSABP的重点是进行大规模的临床试验的进行，旨在提高发展这些疾病的人的护理标准，生活质量和生存，以及乳腺癌和结直肠癌预防研究的进行。我们目前和计划的研究旨在改善这些疾病的预防和治疗。