Novel Combinations of Radiation and Immunotherapy

放射治疗和免疫治疗的新组合

• 批准号: 8763573
• 负责人: Jennifer Jones
• 金额: $ 3.69万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8763573
• 关键词: Cells; Cessation of life; Combined Modality Therapy; Disease; Disseminated Malignant Neoplasm; Goals; Immune; Immune response; Immunotherapeutic agent; Immunotherapy; Malignant Neoplasms; Mediating; Methods; Radiation; Radiation therapy; Systemic Therapy; Therapeutic; Time; Unresectable; irradiation; novel; palliative; radiation effect; sarcoma; soft tissue; tumor; tumor microenvironment

Metastatic or unresectable disease is the direct or indirect cause of 90% of all cancer deaths, and curative therapies for the treatment of metastatic cancers are rare. My ultimate goal is to develop methods that that enable us to achieve systemic tumor control after localized irradiation, when localized radiation therapy is indicated. There are no broadly effective systemic therapies for the treatment of metastatic soft tissue sarcomas, but localized palliative radiation therapy is commonly used and provides a therapeutic opportunity if an anti-tumor immune response is induced by immunotherapies administered at the time of the palliative radiation. Combining radiation with immunotherapy is a promising method for treating metastatic malignancies, and we hypothesized that the effects of radiation (RT) on immune cells in the tumor microenvironment will determine the utility of different immunotherapeutic (IT) methods in RT + IT combination therapies. We are identifying immunotherapies that combine effectively with radiation to promote systemic immune-mediated regression of metastatic disease.

转移性或不可切除的疾病是所有癌症死亡的90%的直接或间接原因，并且用于治疗转移性癌症的治愈性疗法是罕见的。我的最终目标是开发出一种方法，使我们能够在局部照射后实现全身肿瘤控制，当局部放射治疗是指。对于转移性软组织肉瘤的治疗，没有广泛有效的全身疗法，但是局部姑息性放射疗法是常用的，并且如果在姑息性放射时施用的免疫疗法诱导抗肿瘤免疫应答，则提供治疗机会。放射与免疫治疗相结合是治疗转移性恶性肿瘤的一种有前途的方法，我们假设放射（RT）对肿瘤微环境中免疫细胞的影响将决定不同免疫（IT）方法在RT + IT联合治疗中的效用。我们正在寻找能够与放射有效结合的免疫疗法，以促进全身免疫介导的转移性疾病消退。联合收割机。