Human Subject Recruitment & Management

项目总结(见说明)： 人类受试者征聘和管理核心(HSRM)将建立人类受试者登记处，以支持收集潜在研究参与者的信息并将其分发给调查人员。该登记将包括由P30研究人员研究的具有言语、语言和/或听力障碍的广泛人群(目标1)，特别强调登记NIDCD高度优先的人群，并对关键患者群体进行更广泛的初步评估和筛查：自闭症谱系障碍、基于语言的学习障碍和老年人(目标2)。这些患者中的每一个都是高度关注公共卫生的人，也是非传染性疾病优先事项的主要焦点。它们也经常出现在Roxelyn和Richard Pepper传播科学和疾病部(CSD)的诊所。然而，对这些人群的研究涉及劳动和时间密集型的筛查和诊断工作，如果实验室没有广泛和专门的资源来评估每个特定人群，这可能是令人望而却步的。CORE 1将为这些重点患者群体管理一套通用的筛查工具，以减轻这一负担，并促进对这些关键人群的研究。这项筛查将补充CSD和语言学中各个实验室提供的数据，专门针对每个人群。将雇用征聘登记处协调人员，集中每个调查员目前分别进行的劳动密集型征聘和筛选工作，并将这些征聘数据保存在登记处，以供调查员查阅。核心1的工作人员将与IRB联系，以促进通过注册中心获得的科目的研究登记，并可能在实验室之间交换数据，以促进跨实验室合作和新的翻译研究努力。这一核心将与核心2密切互动，以优化基于软件的工具，以支持登记册数据库。总而言之，这些目标将为人类学科招聘的劳动密集型任务提供集中的、具有成本效益的资源，重点是跨实验室研究的语言、语言和/或听力障碍人群，以及NIDCD特别优先的特殊人群。研究参与者综合登记册的提供将大大增加各实验室可获得的受试者数量，并增加合作机会。

PROJECT SUMMARY (See instructions): The Human Subject Recruitment and Management Core (HSRM) will establish a Human Subjects Registry to support the collection and distribution of potential research participant information to investigators. The registry will include an extensive range of populations with speech, language, and/or hearing disorders studied by P30 investigators (Aim 1), with special emphasis on enrolling populations of high priority to NIDCD and performing more extensive initial assessment and screening of key patient populations: autism spectrum disorders, language based learning disorders, and older adults (Aim 2). Each of these patient populations is of high public health concern and a major focus of NIDCD priorities. They are also commonly seen in the clinics of the Roxelyn and Richard Pepper Department of Communication Sciences and Disorders (CSD). However, research with these populations involves labor and time intensive screening and diagnostic work, which can be prohibitive to laboratories without extensive and specialized resources in place for the assessment of each particular population. Core 1 will administer a common set of screening tools to these focused patient groups in order to reduce this burden, and facilitate research with these key populations. This screening will complement data contributed by individual laboratories in CSD and Linguistics, specializing with each population. Recruitment registry coordination staff will be hired to centralize the labor intensive recruitment and screening efforts currently performed separately by each Investigator, as well as to maintain these recruitment data in the registry for investigator access. Core 1 staff will liaise with the IRB to facilitate study enrollment of subjects obtained through the registry, and potential data exchange across laboratories that will facilitate cross-laboratory collaborations and new translational research endeavors. This core will interact closely with Core 2 to optimize software based tools to support the registry database. Together, these aims will provide a centralized, cost efficient resource for the labor intensive task of human subject recruitment, with an emphasis on speech, language, and/or hearing impaired populations studied across laboratories, and special populations of particular priority to NIDCD. The availability of a comprehensive registry of research participants will substantially increase the quantity of subjects available across laboratories, and increase opportunities for collaboration.