Human Subject Recruitment & Management

项目总结（见说明）： 人类受试者招募和管理中心（HSRM）将建立人类受试者登记处，以支持收集潜在研究参与者信息并将其分发给研究者。该登记研究将包括P30研究者研究的广泛的言语、语言和/或听力障碍人群（目标1），特别强调招募NIDCD的高优先级人群，并对关键患者人群进行更广泛的初步评估和筛查：自闭症谱系障碍、语言学习障碍和老年人（目标2）。这些患者群体中的每一个都是高度公共卫生关注的问题，也是NIDCD优先事项的主要焦点。它们也常出现在Roxelyn和Richard Pepper传播科学和疾病部（CSD）的诊所。然而，对这些人群的研究涉及劳动和时间密集型的筛查和诊断工作，这对于没有广泛和专门资源用于评估每个特定人群的实验室来说可能是禁止的。核心1将为这些重点患者群体提供一套通用的筛查工具，以减轻这一负担，并促进对这些关键人群的研究。这一筛查将补充CSD和语言学各实验室提供的数据，这些实验室专门研究每个人群。将聘请招募登记协调工作人员，以集中目前由每位研究者单独进行的劳动密集型招募和筛选工作，并将这些招募数据保存在登记研究中，以供研究者访问。核心1工作人员将与IRB联络，以促进通过登记研究获得的受试者的研究入组，以及实验室间的潜在数据交换，这将促进实验室间的合作和新的转化研究工作。该核心将与核心2密切互动，以优化基于软件的工具，支持登记册数据库。总之，这些目标将为人类受试者招募的劳动密集型任务提供集中的、具有成本效益的资源，重点是跨实验室研究的言语、语言和/或听力受损人群，以及对NIDCD特别优先的特殊人群。研究参与者全面登记的可用性将大大增加实验室之间可用的受试者数量，并增加合作机会。

PROJECT SUMMARY (See instructions): The Human Subject Recruitment and Management Core (HSRM) will establish a Human Subjects Registry to support the collection and distribution of potential research participant information to investigators. The registry will include an extensive range of populations with speech, language, and/or hearing disorders studied by P30 investigators (Aim 1), with special emphasis on enrolling populations of high priority to NIDCD and performing more extensive initial assessment and screening of key patient populations: autism spectrum disorders, language based learning disorders, and older adults (Aim 2). Each of these patient populations is of high public health concern and a major focus of NIDCD priorities. They are also commonly seen in the clinics of the Roxelyn and Richard Pepper Department of Communication Sciences and Disorders (CSD). However, research with these populations involves labor and time intensive screening and diagnostic work, which can be prohibitive to laboratories without extensive and specialized resources in place for the assessment of each particular population. Core 1 will administer a common set of screening tools to these focused patient groups in order to reduce this burden, and facilitate research with these key populations. This screening will complement data contributed by individual laboratories in CSD and Linguistics, specializing with each population. Recruitment registry coordination staff will be hired to centralize the labor intensive recruitment and screening efforts currently performed separately by each Investigator, as well as to maintain these recruitment data in the registry for investigator access. Core 1 staff will liaise with the IRB to facilitate study enrollment of subjects obtained through the registry, and potential data exchange across laboratories that will facilitate cross-laboratory collaborations and new translational research endeavors. This core will interact closely with Core 2 to optimize software based tools to support the registry database. Together, these aims will provide a centralized, cost efficient resource for the labor intensive task of human subject recruitment, with an emphasis on speech, language, and/or hearing impaired populations studied across laboratories, and special populations of particular priority to NIDCD. The availability of a comprehensive registry of research participants will substantially increase the quantity of subjects available across laboratories, and increase opportunities for collaboration.