Improving the use of chemotherapy by targeting the inflammatory response

通过针对炎症反应改善化疗的使用

• 批准号: nhmrc : 632848
• 负责人: A/Pr Andrew Katsifis
• 金额: $ 38.07万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-use-chemotherapy-inflammatory-response/78136
• 关键词: Improving; use; chemotherapy; targeting; inflammatory

Patient differences in clearance of anti-cancer drugs have a major impact on the success of chemotherapy. Benefit is lost if the drug is cleared too rapidly, while slow elimination causes toxicity. We will use well characterised mouse models that mirror the human situation to study the causes and effects of reduced drug metabolism in cancer. The data will guide future human studies that will result in improved diagnostic and therapeutic interventions to improve the tolerance of chemotherapy.

患者抗癌药物清除率的差异对化疗的成功有重大影响。如果药物清除太快，就会失去益处，而清除缓慢会导致毒性。我们将使用反映人类情况的特征良好的小鼠模型来研究癌症中药物代谢减少的原因和影响。这些数据将指导未来的人体研究，从而改进诊断和治疗干预措施，以提高化疗的耐受性。