"Interventions to Slow Aging in Humans: Are We Ready?"

“减缓人类衰老的干预措施：我们准备好了吗？”

• 批准号: 8597898
• 负责人: VALTER D. LONGO
• 金额: $ 1.5万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597898
• 关键词: Adverse effects; Affect; Age; Aging; Biomedical Research; Birth; Cardiovascular Diseases; Chronic; Chronic Disease; Clinical; Clinical Drug Development; Clinical Trials; Consensus; Consensus Workshop; Developed Countries; Developing Countries; Development; Diabetes Mellitus; Diet; Disease; Drug Targeting; Educational workshop; Experimental Animal Model; Funding; Gene Mutation; Gerontology; Goals; Government; Growth; Guidelines; Health; Health Benefit; Healthcare; Human; Hypertension; Incidence; Industry; Intervention; Italy; Learning; Life Expectancy; Longevity; Macaca mulatta; Malignant Neoplasms; Measures; Mutation; Nerve Degeneration; Nutrient; Pathology; Pathway interactions; Pharmaceutical Preparations; Pharmacologic Substance; Population; Prevalence; Regimen; Request for Applications; Research; Risk Factors; Rodent; Safety; Sicily; Signal Pathway; Social Welfare; Structure; System; Taxes; Techniques; Testing; United States; Work; age related; detection of nutrient; dietary restriction; drug development; drug discovery; drug testing; genetic manipulation; improved; loss of function; pre-clinical; public health relevance; success; symposium; trend; tumor

DESCRIPTION (provided by applicant): Human aging and age-associated diseases are becoming one of the biggest challenges faced by developed and developing countries. The financial burden caused by these chronic diseases is already overwhelming and currently taxing the healthcare and welfare systems of developed nations, but if present trends continue, the challenges could overwhelm the systems. In rodents, both dietary restriction (DR) and mutations in nutrient and growth signaling pathways can extend longevity by 30-50% but also lower the incidence of age-related loss of function and disease, including tumors and neurodegeneration. This application requests funds to support the Consensus Workshop "Interventions to Slow Aging in Humans: Are We Ready?" to be held in Erice, Sicily, Italy, from October 8-13, 2013. The main aim of the consensus workshop is to bring together leading experts in gerontology, drug discovery and development to begin to obtain consensus related to the discovery and development of safe interventions to slow aging and increase healthspan in humans. The goals of the conference are: 1) To determine the most suitable candidate healthspan interventions/drugs for clinical development, 2) To provide a forum for the discussion of state of the art techniques for drug discovery related to aging and age-related disease, 3) To stimulate clinical trials to begin the testing of drugs generated by basic biogerontology research and discuss the potential pitfalls and side effects of each drug.

描述（由申请人提供）：人类衰老和与年龄相关的疾病正在成为发达国家和发展中国家面临的最大挑战之一。这些慢性疾病造成的经济负担已经不堪重负，目前正在给发达国家的医疗保健和福利系统带来负担，但如果目前的趋势继续下去，这些挑战可能会压垮这些系统。在啮齿动物中，饮食限制 (DR) 以及营养和生长信号通路的突变可以将寿命延长 30-50%，同时还可以降低与年龄相关的功能丧失和疾病（包括肿瘤和神经退行性疾病）的发生率。本申请请求资金支持共识研讨会“人类延缓衰老的干预措施：我们准备好了吗？”将于 2013 年 10 月 8 日至 13 日在意大利西西里岛埃里切举行。共识研讨会的主要目的是汇集老年学、药物发现和开发方面的领先专家，开始就发现和开发减缓衰老和延长人类健康寿命的安全干预措施达成共识。会议的目标是：1) 确定最适合临床开发的候选健康寿命干预措施/药物，2) 提供一个论坛，讨论与衰老和年龄相关疾病相关的药物发现的最先进技术，3) 刺激临床试验，开始测试基础生物老年学研究产生的药物，并讨论每种药物的潜在陷阱和副作用。