Modeling Optimal Strategies to Prevent Cardiovascular Events in Older Adults

模拟预防老年人心血管事件的最佳策略

• 批准号: 8416372
• 负责人: Michelle Christina Odden
• 金额: $ 13.75万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8416372
• 关键词: Adult; Adverse effects; Affect; Age; Aging; American; Antihypertensive Agents; Benefits and Risks; California; Cardiovascular Diseases; Cardiovascular system; Cholesterol; Clinical; Clinical Sciences; Cohort Studies; Collaborations; Comorbidity; Computer Simulation; Computers; Data; Decision Analysis; Diabetes Mellitus; Disease; Dyslipidemias; Elderly; Epidemiologist; Epidemiology; Equilibrium; Event; Foundations; Funding; Future; Gerontology; Goals; Health; Health Professional; Hypertension; Incidence; Individual; Inflammation; Institutes; Intervention; Investigation; Knowledge; Learning; Life; Literature; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Mission; Modeling; Morbidity - disease rate; Myocardial Infarction; NCI Scholars Program; Obesity; Older Population; Outcome; Pathway interactions; Personal Satisfaction; Persons; Pharmaceutical Preparations; Physical Function; Physiological; Policies; Polypharmacy; Population; Prevalence; Prevention; Prevention strategy; Provider; Public Health; Public Health Practice; Quality of life; Quality-Adjusted Life Years; Recommendation; Relative (related person); Renal function; Research; Research Personnel; Research Support; Research Training; Risk; Risk Factors; San Francisco; Science; Stroke; Training; Translating; Translational Research; United States; United States National Institutes of Health; Universities; age related; aged; base; burden of illness; cardiovascular disorder prevention; cardiovascular disorder risk; career; career development; clinical practice; evidence base; functional status; hypertension treatment; improved; markov model; middle age; mortality; multidisciplinary; novel; prevent; programs; research to practice; simulation; skills

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development Award application will provide an intensive research, training, and career development program for Dr. Michelle Odden, an epidemiologist and developing investigator at the University of California, San Francisco (UCSF). Her long-term career goal is to become a leader in the evidence-based prevention of cardiovascular disease (CVD) and related comorbid conditions in elderly adults. Older adults are living longer and healthier lives, yet much of the current literature on CVD epidemiology and prevention has been derived from younger populations. In this application, Dr. Odden will develop a comprehensive evidence base for prevention of CVD events in adults aged 75 years and older. Guided by her mentorship team, Dr. Odden will identify the strongest risk factors for CVD in the Cardiovascular Health Study, an ongoing NIH-funded cohort study of elderly adults. She will use the results of these analyses to inform computer simulations of CVD in older adults, in order to identify the most promising interventions for CVD prevention at the lowest risk for unintended side effects. Dr. Odden will conduct these simulations with the CHD Policy Model, an established computer model of CVD in the U.S. population. To achieve these goals, Dr. Odden and her mentors have developed the following specific aims:1) To describe the epidemiology of CVD events in adults 75 years and older, and to identify the strongest determinants of CVD events, among both traditional and age-related risk factors; 2) To forecast CVD incidence, prevalence, mortality, and quality of life in U.S. adults aged 75 years and older, by incorporating in-depth, novel epidemiological data into an established CVD computer model; 3) To estimate the potential impact of prevention strategies for CVD in U.S. adults aged 75 years and older on the extension of healthy life years, based on an established CVD computer model. The long term goal of this research is to prevent CVD events in adults over 75, and to extend the healthy years of life for older adults. This research supports the National Institutes of Health's mission to prevent disease and improve the health and well-being of Americans. The primary training goals of this application are to build a foundation of knowledge and skill set that will prepare Dr. Odden to be a successful independent researcher in translational research - from research to practice - in older adults. Through the training and the mentorship of a multidisciplinary team comprised of senior investigators at UCSF, and accomplished external advisors, she will learn the principles of gerontologic clinical science and cardiovascular prevention, and expand her methodological expertise to include forecasting and decision analysis methods. Additional training in implementation and dissemination science will enable her to translate her research findings into public health and clinical practice recommendations. She will participate in the Clinical and Translational K Scholars Program, offered by the UCSF Clinical and Translational Science Institute, which will offer crucial support and mentoring as she develops her research program in translational aging research.

描述（由申请人提供）：该指导研究科学家发展奖申请将为加州大学旧金山弗朗西斯科（UCSF）的流行病学家和发展研究者Michelle Odden博士提供密集的研究，培训和职业发展计划。她的长期职业目标是成为老年人心血管疾病（CVD）和相关共病疾病循证预防的领导者。老年人的寿命更长，生活更健康，但目前关于CVD流行病学和预防的文献大多来自年轻人群。在这项申请中，Odden博士将开发一个全面的证据基础，用于预防75岁及以上成年人的CVD事件。在她的导师团队的指导下，Odden博士将在心血管健康研究中确定心血管疾病的最强风险因素，这是一项正在进行的NIH资助的老年人队列研究。她将利用这些分析的结果来为老年人CVD的计算机模拟提供信息，以确定最有希望的CVD预防干预措施，同时降低意外副作用的风险。Odden博士将使用CHD政策模型进行这些模拟，CHD政策模型是美国人口中CVD的一个既定计算机模型。为了实现这些目标，Odden博士和她的导师们制定了以下具体目标：1）描述75岁及以上成年人CVD事件的流行病学，并在传统和年龄相关的风险因素中确定CVD事件的最强决定因素; 2）通过将深入的新流行病学数据纳入已建立的CVD计算机模型，预测美国75岁及以上成年人的CVD发病率，患病率，死亡率和生活质量; 3）根据已建立的CVD计算机模型，估计美国75岁及以上成年人CVD预防策略对延长健康寿命年的潜在影响。这项研究的长期目标是预防75岁以上成年人的心血管疾病事件，并延长老年人的健康寿命。这项研究支持美国国立卫生研究院的使命，以预防疾病和改善美国人的健康和福祉。该应用程序的主要培训目标是建立知识和技能的基础，这将使Odden博士成为一名成功的独立研究人员，从事转化研究-从研究到实践-在老年人中。通过培训和由UCSF高级研究人员和资深外部顾问组成的多学科团队的指导，她将学习老年临床科学和心血管预防的原则，并扩展她的方法学专业知识，包括预测和决策分析方法。实施和传播科学的额外培训将使她能够将她的研究成果转化为公共卫生和临床实践建议。她将参加由UCSF临床和转化科学研究所提供的临床和转化K学者计划，该计划将为她在转化衰老研究方面的研究计划提供重要的支持和指导。