Integrated Training in Pharmacological Sciences

参见说明）： 西奈山药理科学综合培训计划旨在提供严格的 跨学科的博士前培训的基本机制，控制生理和 病理生理过程和药物作用。这是该计划的目标，提供教育活动， 和研究培训，将基本的机械发现与治疗方式联系起来， 确定药物靶点和开发先导治疗化合物。培训计划旨在 实现深入的培训，加上广阔的视野，使受训者能够将新兴的 在整个职业生涯中，该计划还旨在创造一个学习环境，促进 独立思考和个人分析能力，同时培养协作能力 学习和研究环境。该计划结合了综合教学培训的核心， 药理学和系统生物学，提供生物化学，结构， 生理学和疾病病理生理学背景下的生物学、遗传学、细胞和分子生物学。 各种规模的系统问题的计算和建模方法，大型数据集， 贯穿始终的流行病学问题，以及使学生能够获得的支持 不同的量化技能进入水平，以取得成功。本课程采用综合主动学习 在基础课程和高级课程中，通过具体的教学创新来加强这种方法。他们 包括异步讨论、课堂讨论和使用同行评估方法 为学生未来职业的这一主要特征做好准备。参加本次培训的49名教师 该计划来自13个学术部门和研究所，包括临床和基础的混合 科学的重点。他们的研究项目为项目学员提供了解决重要问题的机会。 具有强大药理学和/或系统生物学的生物医学的不同领域中的问题 界面和平移势。跨学科和翻译培训环境以及 该计划的结构促进我们的学员进入独立的科学事业。 相关性（参见说明）： 突破性进展，产生新的药物，改善不同的人类疾病，产生新的诊断或 新的治疗策略越来越多地依赖于应用定量计算的研究人员， 疾病和药物相互作用的复杂生物学方法。我们的目标是培养这些技能， 博士和MD/博士生，使他们能够实现下一代的突破。

See instructions): The Integrated Training in Pharmacological Sciences program at Mount Sinai aims to provide rigorous interdisciplinary pre-doctoral training in the fundamental mechanisms that control physiological and pathophysiological processes and drug action. It is the goal of this program to provide educational activities and research training that connect the basic mechanistic findings to therapeutic modalities including the identification of drug targets and development of lead therapeutic compounds. The training program seeksto achieve in-depth training coupled with a broad perspective that equips the trainees to incorporate emerging new areas throughout their careers. The program also seeks to create a learning environment that promotes independent thinking and individual analytical skills, while fostering the ability to work in collaborative learning and research environments. The program combines a core of integrated didactic training in Pharmacology and Systems Biology that provides grounding in core principles of biochemistry, structural biology, genetics, cellular and molecular biology within a context of physiology and disease pathophysiology. Computational and modeling approaches to systems problems at various scales, to large data sets and to epidemiological problems are introduced throughout, together with support that enables students with different entering levels of quantitative skills to succeed. This curriculum uses an integrated active learning approach in both basic and advanced courses that is enhanced by specific pedagogical innovations. They include asynchronous discussions as well as in-class discussions and use of peer evaluation methodologies that prepare students for this major feature of their future careers. The 49 participating faculty of this training program are drawn from 13 academic departments and institutes that include a mix of clinical and basic science emphases. Their research projects provide opportunities for program trainees to tackle important problems in diverse areas of biomedicine that have strong pharmacological and/or systems biology interfaces and translational potential. The interdisciplinary and translational training environment and the structure of the program foster the entry of our trainees into independent scientific careers. RELEVANCE (See instructions): Breakthroughs that yield new drugs that ameliorate different human diseases, that yield new diagnostics or new therapeutic strategies depend more and more upon researchers who apply quantitativecomputational methods to the complex biology of disease and drug interactions. We aim to foster these skills in talented PhD and MD/PhD students, enabling them to achieve the next generation of breakthroughs.