Training in Neurostatistics and Neuroepidemiology

这是请求继续支持2004年在哈佛公共卫生学院（HSPH）启动的神经统计学和神经流行病学培训项目。该基金将由生物统计学系管理。它将涉及一个有成就、有经验和多学科培训教员的积极参与，其中包括HSPH的11名初级培训教员和哈佛附属医院的23名二级培训教员。这些教员在HSPH生物统计和流行病学系以及哈佛医学院任职。拟议的培训计划旨在满足神经系统疾病研究的两个迫切需求：需要训练有素的生物统计学家，他们了解并致力于神经科学和神经病学的研究；需要训练有素的神经学家，他们了解并致力于利用定量研究方法。为满足这些关键需求，本基金拟培养3名生物统计学博士预科生、1名生物统计学博士后和2名流行病学博士后。生物统计学学员将在神经系统疾病研究相关领域发展方法学专业知识，包括生存分析、纵向研究、临床试验、功能磁共振成像分析和遗传研究，以及在几种神经系统疾病及其伴随的测量和分析技术方面的实质性专业知识。流行病学培训生将成为神经病学（或相关领域）的高素质医学专家。这些受训者将发展流行病学和生物统计学方法方面的专业知识，使他们能够在临床和转化神经疾病研究方面追求成功的学术事业。学员将在该项目中度过至少两年的时间。该项目将利用HSPH在生物统计和流行病学方法方面的强大培训传统，以及哈佛大学在神经疾病研究方面丰富多样的资源。学员将完成生物统计学和流行病学方法的课程，他们将积极参与合作研究经验，包括通过哈佛神经发现中心提供的许多机会。

This is a request for continuation of support for a training program in Neurostatistics and Neuroepidemiology launched in 2004 at the Harvard School of Public Health (HSPH). The Grant will be administered through the Department of Biostatistics. It will involve active participation by an accomplished, experienced, and multidisciplinary training faculty, including 11 primary trainers at HSPH and 23 secondary trainers at the affiliated Harvard hospitals. These faculty members have appointments at the Departments of Biostatistics and Epidemiology at HSPH and at Harvard Medical School. The proposed training program aims to serve two pressing needs in neurologic diseases research: the need for well-trained biostatisticians who have an understanding of and commitment to research in neuroscience and neurology and the need for highly trained neurologists who have an understanding of and commitment to utilization of quantitative research methods. To serve these critical needs, this grant proposes to train three pre-doctoral students and one post-doctoral student in biostatistics and two post-doctoral students in epidemiology. The biostatistics trainees will develop methodologic expertise in areas relevant to neurologic diseases research, including survival analysis, longitudinal studies, clinical trials, fMRI analysis, and genetic studies, and substantive expertise in several neurologic diseases and their accompanying measurement and analysis techniques. The epidemiology trainees will be highly qualified MD specialists in neurology (or related field). These trainees will develop expertise in epidemiologic and biostatistical methods, enabling them to pursue successful academic careers in clinical and translational neurologic diseases research. Trainees will spend a minimum of two years in the Program. The Program will capitalize on the strong tradition of training in biostatistical and epidemiologic methods at HSPH and on the rich and varied resources in neurologic diseases research available at Harvard. Trainees will complete coursework in biostatistical and epidemiologic methods and they will actively engage in collaborative research experiences, including many opportunities offered through the Harvard NeuroDiscovery Center.