Insulin Resistance in Childhood

这是针对席尔瓦·阿尔斯兰尼安的面向患者的研究(POR)中K24的竞争性续订申请， 匹兹堡大学医学院儿童医院医学博士。申请人原裁决书 为POR研究儿童生长发育期间的胰岛素抵抗提供了支持， 指导初级教员和研究员，推动新方向的研究，并在POR中发挥领导作用 地方、国家和国际上的。所有这些目标都以出众的严谨执行， 应聘者已经成功地完成了以下工作：1)竞争性地更新了她的R01(2R01 HD027503)；2)获得了新的独立NIH资金，如PI(1U01 DK063704)，以及几个 药物试验；3)通过获得新的资金来提高她的指导承诺，因为她是Follow的PI 培训补助金(T32 DK63686)和初级教师发展补助金(K12 DK63704)，均为儿科 糖尿病；4)在她自己的机构(1R01-HD38425和5U01)建立了POR的新合作 DK061230；皮玛莎·马库斯博士)以及与其他学术机构的合作(1R01 DK071485；Pi，舒梅 5)竞争性地续签了GCRC补助金(5M01RR00084)，具有 成绩优异，在匹兹堡儿童医院担任院长；成为该医院董事会成员 内分泌研究员基金会，一个主要也是唯一的使命是教育的全国性组织 和对全国内分泌研究员的研究支持；7)在#年增加了儿科医生调查员队伍 通过吸引和指导机构内外的新研究员/教职员工； 在指导新成立的体重管理和健康中心(WMWC)方面发挥领导作用 匹兹堡儿童医院；最后但并非最不重要的是，获得了匹兹堡大学的首届 理查德·L·戴医学中心儿科学教授。 这份续签申请建议：1)在以下领域继续担任PI在POR方面的领导 儿童肥胖、胰岛素抵抗、2型糖尿病和心血管疾病是主要的公共卫生问题 本世纪的问题；2)为初级教师、研究员和医学生提供持续的指导； 3)对儿童胰岛素抵抗及其原因、并发症和控制进行创新性研究 战略。对这些活动的支持将使阿尔斯兰尼博士能够进一步加强和扩大 儿童肥胖和胰岛素抵抗的研究范围，但更重要的是，有助于学术 培养将为全球儿童作出贡献的年轻和即将到来的临床医生和研究人员 通过开发干预、预防和治疗的新模式来控制肥胖。

This is a competing renewal application for a K24 in patient-oriented research (POR) for Silva Arslanian, M.D. of the Children's Hospital University of Pittsburgh, School of Medicine. The applicant's original award provided support for POR for investigating insulin resistance during childhood growth and development, mentoring of junior faculty and fellows, advancing the research in new directions, and leadership in POR locally, nationally, and internationally. All of these aims have been executed with outstanding rigor, and the candidate has been successful in accomplishing the following: 1) Competitively renewed her R01 (2R01 HD027503); 2) Obtained new independent NIH funding as PI (1U01 DK063704), and funding for several pharmaceutical trials; 3) Advanced her mentoring commitment by obtaining new funding as PI for a felllow training grant (T32 DK63686) and junior faculty development grant (K12 DK63704), both in pediatric diabetes; 4) Established new collaborations in POR at her own institution (1R01- HD38425, and 5U01 DK061230; PI, Marsha Marcus, Ph.D.) and with other academic institutions (1R01 DK071485; PI, Shumei Sun, Ph.D., Wright State University); 5) Competitively renewed the GCRC grant (5M01RR00084), with an outstanding score, at Children's Hospital of Pittsburgh, where she is director; 6) Became a board member of the Endocrine Fellows Foundation, a national organization whose primary and sole mission is the education and research support of endocrine fellows nationally; 7) Increased the pool of pediatrician investigators in POR by attracting and mentoring new fellows/faculty from within and outside the institution; 9) Assumed a leadership role in directing the newly founded Weight Management & Wellness Center (WMWC) at Children's Hospital of Pittsburgh; and, last but not least, received the inaugural University of Pittsburgh Medical Center Richard L. Day Endowed Chair in Pediatrics. This renewal application proposes to: 1) Continue the leadership of the PI in POR in the area of childhood obesity, insulin resistance, type 2 diabetes, and cardiovascular disease, major public health problems of this millennium; 2) Provide ongoing mentoring to junior faculty, fellows, and medical students; and 3) To conduct innovative research in childhood insulin resistance, its causes, complications and control strategies. Support for these activities will enable Dr. Arslanian to further strengthen and expand the research scope of childhood obesity and insulin resistance but, more importantly, contribute to the academic development of young and upcoming clinician-investigators who will contribute to the global childhood obesity control by developing new paradigms of intervention, prevention and treatment.