Insulin Resistance in Childhood

这是一个竞争性的更新申请K24在以患者为导向的研究（POR）的席尔瓦阿尔斯拉尼安， M.D.匹兹堡大学医学院儿童医院的一名医生。申请人的原始裁决 为POR研究儿童生长发育期间的胰岛素抵抗提供支持， 指导初级教师和研究员，推进新方向的研究，并在POR的领导 在当地，国内，国际上。所有这些目标都得到了非常严格的执行， 候选人成功地完成了以下工作：1）竞争性地更新了R 01（2 R 01 HD 027503）; 2）作为PI（1U 01 DK 063704）获得了新的独立NIH资助， 药物试验; 3）通过获得新的资金作为PI为一个felllow 培训补助金（T32 DK 63686）和初级教师发展补助金（K12 DK 63704），均为儿科 糖尿病; 4）在她自己的机构建立了新的POR合作（1 R 01-HD 38425和5 U 01 DK 061230; PI，Marsha Marcus，Ph.D.）和其他学术机构（1 R 01 DK 071485; PI，Shumei 孙博士，赖特州立大学）; 5）竞争性地更新了GCRC赠款（5 M01 RR 00084）， 她在匹兹堡儿童医院担任主任，成绩优异; 6）成为 内分泌研究员基金会，一个全国性组织，其主要和唯一的使命是教育 和研究支持的内分泌研究员全国; 7）增加了儿科研究人员的池， 通过吸引和指导来自机构内外的新研究员/教员来提高POR; 9）假设 在指导新成立的体重管理和健康中心（WMWC）的领导作用， 匹兹堡儿童医院;最后但并非最不重要的是，匹兹堡大学成立 医学中心理查德·L.儿科的日间捐赠椅子。 本续期申请建议：1）继续在POR中PI在以下领域的领导 儿童肥胖、胰岛素抵抗、2型糖尿病和心血管疾病，主要公共卫生 2）为初级教师、研究员和医学生提供持续的指导; 3）对儿童胰岛素抵抗及其原因、并发症和控制进行创新性研究 战略布局对这些活动的支持将使阿尔斯拉尼安博士能够进一步加强和扩大 儿童肥胖和胰岛素抵抗的研究范围，但更重要的是，有助于学术 培养年轻和即将到来的临床研究人员，他们将为全球儿童做出贡献 通过开发新的干预、预防和治疗模式来控制肥胖。

This is a competing renewal application for a K24 in patient-oriented research (POR) for Silva Arslanian, M.D. of the Children's Hospital University of Pittsburgh, School of Medicine. The applicant's original award provided support for POR for investigating insulin resistance during childhood growth and development, mentoring of junior faculty and fellows, advancing the research in new directions, and leadership in POR locally, nationally, and internationally. All of these aims have been executed with outstanding rigor, and the candidate has been successful in accomplishing the following: 1) Competitively renewed her R01 (2R01 HD027503); 2) Obtained new independent NIH funding as PI (1U01 DK063704), and funding for several pharmaceutical trials; 3) Advanced her mentoring commitment by obtaining new funding as PI for a felllow training grant (T32 DK63686) and junior faculty development grant (K12 DK63704), both in pediatric diabetes; 4) Established new collaborations in POR at her own institution (1R01- HD38425, and 5U01 DK061230; PI, Marsha Marcus, Ph.D.) and with other academic institutions (1R01 DK071485; PI, Shumei Sun, Ph.D., Wright State University); 5) Competitively renewed the GCRC grant (5M01RR00084), with an outstanding score, at Children's Hospital of Pittsburgh, where she is director; 6) Became a board member of the Endocrine Fellows Foundation, a national organization whose primary and sole mission is the education and research support of endocrine fellows nationally; 7) Increased the pool of pediatrician investigators in POR by attracting and mentoring new fellows/faculty from within and outside the institution; 9) Assumed a leadership role in directing the newly founded Weight Management & Wellness Center (WMWC) at Children's Hospital of Pittsburgh; and, last but not least, received the inaugural University of Pittsburgh Medical Center Richard L. Day Endowed Chair in Pediatrics. This renewal application proposes to: 1) Continue the leadership of the PI in POR in the area of childhood obesity, insulin resistance, type 2 diabetes, and cardiovascular disease, major public health problems of this millennium; 2) Provide ongoing mentoring to junior faculty, fellows, and medical students; and 3) To conduct innovative research in childhood insulin resistance, its causes, complications and control strategies. Support for these activities will enable Dr. Arslanian to further strengthen and expand the research scope of childhood obesity and insulin resistance but, more importantly, contribute to the academic development of young and upcoming clinician-investigators who will contribute to the global childhood obesity control by developing new paradigms of intervention, prevention and treatment.