PROSPECTIVE MULTICENTER STUDY OF BRONCHIOLITIS ADMISSIONS: ETIOLOGY AND DISPOSIN

细支气管炎入院的前瞻性多中心研究：病因和处置

• 批准号: 8167363
• 负责人: STEPHEN John TEACH
• 金额: $ 3.08万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167363
• 关键词: Admission activity; Bronchiolitis; Caring; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Continuous Positive Airway Pressure; Disease; Etiology; Family; Fostering; Funding; Grant; Guidelines; Home environment; Hospitals; Infant; Infection; Institution; Intensive Care; Intubation; Multicenter Studies; Research; Research Personnel; Resources; Risk; Role; Source; Testing; United States National Institutes of Health; Virus; high risk; pathogen; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bronchiolitis is the number one reason children younger than 1 year are hospitalized. This common disease is caused by an infection, usually a virus. Despite how common this disease is, little research has studied which children with bronchiolitis are at risk for severe problems, and no research has studied when it is safe for infants to be discharged home from the hospital. The purpose of this study is: (1) To elucidate the role of multiple pathogen infections and to determine the utility of PCR-testing for an infectious etiology; (2) To create high-risk and low-risk clinical rules to predict reliably those children with bronchiolitis who would require continuous positive airway pressure or intubation and those who would not require intensive care; and (3) To develop hospital discharge guidelines that encourage earlier but safe discharges and foster family-centered care.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 毛细支气管炎是1岁以下儿童住院的首要原因。 这种常见的疾病是由感染引起的，通常是病毒。尽管这种疾病是多么常见，但很少有研究研究表明哪些毛细支气管炎儿童有严重问题的风险，也没有研究表明婴儿何时出院回家是安全的。 本研究的目的是：（1）阐明多种病原体感染的作用，并确定PCR检测对感染病原学的实用性;（2）建立高风险和低风险的临床规则，以可靠地预测需要持续气道正压通气或插管的毛细支气管炎儿童和不需要重症监护的儿童;及（3）制定出院指引，鼓励病人尽早安全出院，并促进以家庭为中心的护理。