Incorporating genomics into breast cancer management

将基因组学纳入乳腺癌管理

• 批准号: nhmrc : GNT1151212
• 负责人: Dr Lironne Wein
• 金额: $ 12.64万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/incorporating-genomics-breast-cancer-management/1348976
• 关键词: Incorporating; genomics; into; breast; cancer

This study will investigate use of genomic sequencing in advanced and early breast cancer. We will characterise genetic characteristics of patients who benefit from two different therapies in the metastatic setting. We will use circulating tumour DNA analysis to monitor for and genetically characterise minimal residual disease (MRD) in patients apparently cured by initial therapy. This will thus identify potential therapeutic targets for preventing MRD progressing to metastatic disease.

本研究将探讨基因组测序在晚期和早期乳腺癌中的应用。我们将研究在转移性疾病中受益于两种不同疗法的患者的遗传学特征。我们将使用循环肿瘤DNA分析，以监测和遗传学的微小残留病（MRD）的患者显然治愈的初步治疗。因此，这将确定用于预防MRD进展为转移性疾病的潜在治疗靶点。