肾脏选择性 AMPK 激活剂治疗多囊肾病-猫眼课题宝

肾脏选择性 AMPK 激活剂治疗多囊肾病

批准号：

8646478

负责人：

Ken W Batchelor

金额：

$41.51万

依托单位：

NOVATARG, INC.

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-09-16 至 2014-06-30

来源：

https://reporter.nih.gov/project-details/8646478

关键词：

2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole AVPR2 gene Affinity Animal Model Anions Autosomal Dominant Polycystic Kidney Biguanides Biological Assay Biology Blood Cell Culture Techniques Cell Proliferation Cell membrane Cells Characteristics Chemicals Chronic Clinical Trials Collaborations Collagen Complication Cyst Cystic Fibrosis Transmembrane Conductance Regulator Data Dialysis procedure Diffusion Disease Drug Design Embryo Evaluation Fluids and Secretions Future Growth Human In Vitro Inhibition of Cell Proliferation Innovative Therapy Institutes Kansas Kidney Lactic Acidosis Lead Life Style Ligands Liver Mediating Medical center Metformin Methods Modification Organ Culture Techniques Organic Cation Transporter Outcome POU2F1 gene POU2F2 gene Pathway interactions Patients Pharmaceutical Chemistry Pharmaceutical Preparations Pharmacology Pharmacotherapy Phase Phosphorylation Polycystic Kidney Diseases Polyuria Process Renal Mass Renal function Series Structure-Activity Relationship System Testing Thirst Transplantation Universities Urination Urine V2 Receptors Water analog base cell growth compliance behavior cost design effective therapy experience human FRAP1 protein interest kidney pharmacology novel novel strategies programs public health relevance screening uptake

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英文摘要

DESCRIPTION (provided by applicant): There are approximately 12 million people suffering from autosomal dominant polycystic kidney disease (ADPKD) worldwide. ADPKD is a chronic condition with no effective drug therapies available; dialysis and transplantation are performed at costs of >$2 billion/year in the US. NovaTarg has developed a novel and kidney selective approach to PKD treatment which is expected to generate drugs that block underlying disease processes and to provide innovative therapies for PKD patients.

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